Since the first description of apoptosis four decades ago, great efforts have been made to
elucidate, both in vivo and in vitro, the molecular mechanisms involved in its regulation. …

Cytokines interact with their receptors in the extracellular space to control immune
responses. How the physicochemical properties of the extracellular space influence cytokine …

CD4 + T cell differentiation into multiple T helper (Th) cell lineages is critical for optimal adaptive
immune responses. This report identifies an intrinsic mechanism by which programmed …

Programmed cell death is an event displayed by many different organisms along the
evolutionary scale. In plants, programmed cell death is necessary for development and the …

Cytokines comprise a large family of secreted ligands that are critical for the regulation of
immune homeostasis. Cytokines initiate signaling via dimerization or oligomerization of the …

Dear Editor, In mammals, the intrinsic pathway of apoptosis, or programmed cell death (PCD),
mainly involves activation of the apoptosome-dependent caspase cascade upon binding …

Diverse cellular processes depend on the lysosomal protease system but how cells regulate
lysosomal proteolytic capacity is only partly understood. We show here that cells can …

The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered
unrelated processes, yet cytochrome c (Cc) migrates to the nucleus and even the nucleolus …

Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage
of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines …

Cytokines are highly pleiotropic ligands that regulate the immune response. Here, using
interleukin-6 (IL-6) as a model system, we perform detailed phosphoproteomic and …