Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …

Multiple sclerosis is a complex neurological disease, with ∼20% of risk heritability attributable
to common genetic variants, including >230 identified by genome-wide association …

Importance In 2017, the International Panel on Diagnosis of Multiple Sclerosis revised the
McDonald 2010 criteria for the diagnosis of multiple sclerosis (MS). The new criteria are easier …

We assembled and analyzed genetic data of 47,351 multiple sclerosis (MS) subjects and
68,284 control subjects and establish a reference map of the genetic architecture of MS that …

Background: A promising biomarker for axonal damage early in the disease course of multiple
sclerosis (MS) is neurofilament light chain (NfL). It is unknown whether NfL has the same …

… van Pelt and J. Mescheriakova report no disclosures. N. Makhani received fellowship
funding from the Canadian Network of MS Clinics and has received research support from the …

Importance There is a growing number of therapies that could be administered after the first
symptom of central nervous system demyelination. These drugs can delay multiple sclerosis (…

Objective A recent large-scale study in multiple sclerosis (MS) using the ImmunoChip platform
reported on 11 loci that showed suggestive genetic association with MS. Additional data …

… Mescheriakova … J Consult Clin Psychol 65(2):292–300 … Mescheriakova—declares
no conflict of interests. Tessel F. Runia—declares no conflict of interests. …

Background: Multiple sclerosis (MS) is a complex disease resulting from the joint effect of
many genes. It has been speculated that rare variants might explain part of the missing …