[PDF][PDF] Reshaping endoplasmic reticulum quality control through the unfolded protein response
RL Wiseman, JS Mesgarzadeh, LM Hendershot - Molecular cell, 2022 - cell.com
… Similar to all DnaJ family members, the ERdjs possess a highly conserved J domain through
which they interact with BiP. To date, eight ERdj proteins have been identified within the ER …
which they interact with BiP. To date, eight ERdj proteins have been identified within the ER …
[HTML][HTML] Stress-responsive regulation of extracellular proteostasis
JS Mesgarzadeh, JN Buxbaum, RL Wiseman - Journal of Cell Biology, 2022 - rupress.org
Genetic, environmental, and aging-related insults can promote the misfolding and subsequent
aggregation of secreted proteins implicated in the pathogenesis of numerous diseases. …
aggregation of secreted proteins implicated in the pathogenesis of numerous diseases. …
[HTML][HTML] Defining the functional targets of Cap 'n'collar transcription factors NRF1, NRF2, and NRF3
The NRF transcription factors NRF1, NRF2, and NRF3, are a subset of Cap‘n’collar
transcriptional regulators which modulate the expression of genes harboring antioxidant-response …
transcriptional regulators which modulate the expression of genes harboring antioxidant-response …
Cerebrospinal fluid and vitreous body exposure to orally administered tafamidis in hereditary ATTRV30M (p. TTRV50M) amyloidosis patients
…, A Martins da Silva, N Ferreira, J Mesgarzadeh… - Amyloid, 2018 - Taylor & Francis
Hereditary transthyretin (TTR) amyloidosis associated with the TTRV30M (p.TTRV50M)
mutation presents predominantly as an axonal polyneuropathy, with variable involvement of …
mutation presents predominantly as an axonal polyneuropathy, with variable involvement of …
Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion
B Rius, JS Mesgarzadeh, IC Romine… - Blood …, 2021 - ashpublications.org
Light chain (LC) amyloidosis (AL) involves the toxic aggregation of amyloidogenic
immunoglobulin LCs secreted from a clonal expansion of diseased plasma cells. Current AL …
immunoglobulin LCs secreted from a clonal expansion of diseased plasma cells. Current AL …
[HTML][HTML] ATF6 activation reduces amyloidogenic transthyretin secretion through increased interactions with endoplasmic reticulum proteostasis factors
JS Mesgarzadeh, IC Romine, EM Smith-Cohen… - Cells, 2022 - mdpi.com
The extracellular aggregation of destabilized transthyretin (TTR) variants is implicated in the
onset and pathogenesis of familial TTR-related amyloid diseases. One strategy to reduce …
onset and pathogenesis of familial TTR-related amyloid diseases. One strategy to reduce …
[HTML][HTML] Pheromone-sensing neurons regulate peripheral lipid metabolism in Caenorhabditis elegans
R Hussey, J Stieglitz, J Mesgarzadeh, TT Locke… - PLoS …, 2017 - journals.plos.org
It is now established that the central nervous system plays an important role in regulating
whole body metabolism and energy balance. However, the extent to which sensory systems …
whole body metabolism and energy balance. However, the extent to which sensory systems …
[HTML][HTML] Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans
…, E Witham, E Vanstrum, J Mesgarzadeh… - PLoS …, 2018 - journals.plos.org
The mechanisms by which the sensory environment influences metabolic homeostasis remains
poorly understood. In this report, we show that oxygen, a potent environmental signal, is …
poorly understood. In this report, we show that oxygen, a potent environmental signal, is …
Tafamidis polyneuropathy amelioration requires modest increases in transthyretin stability even though increases in plasma native TTR and decreases in non-native …
C Monteiro, JS Mesgarzadeh, J Anselmo, J Fernandes… - Amyloid, 2023 - Taylor & Francis
Full article: Tafamidis polyneuropathy amelioration requires modest increases in transthyretin
stability even though increases in plasma native TTR and decreases in non-native TTR do …
stability even though increases in plasma native TTR and decreases in non-native TTR do …
Evaluating the role of microRNAs alterations in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) accounts for nearly 90 percent of oral cavity
malignancies and is one of the most widespread oral cancers in the world. The microRNAs (miRNAs …
malignancies and is one of the most widespread oral cancers in the world. The microRNAs (miRNAs …