Glioblastoma (GBM) is a primary tumor of the brain defined by its uniform lethality and
resistance to conventional therapies. There have been considerable efforts to untangle the …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

In many aggressive cancers, such as glioblastoma multiforme, progression is enabled by
local immunosuppression driven by the accumulation of regulatory T cells (Treg) and myeloid-…

Gene therapy offers a multidimensional set of approaches intended to treat and cure
glioblastoma (GBM), in combination with the existing standard-of-care treatment (surgery and …

Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent
work has highlighted that polyamines exert profound roles on the mammalian immune …

As a key component of the standard of care for glioblastoma, radiotherapy induces several
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here, leveraging …

Background Malignant glioma is the most common and lethal primary brain tumour, with
dismal survival rates and no effective treatment. We examined the safety and activity of NSC-…

The mechanisms by which regulatory T cells (Tregs) migrate to and function within the hypoxic
tumor microenvironment are unclear. Our studies indicate that specific ablation of hypoxia-…

The potent immunosuppression induced by glioblastoma (GBM) is one of the primary
obstacles to finding effective immunotherapies. One hallmark of the GBM-associated …

… (J) Survival curves of mice received intracranial implantation of 5 × 10 4 CT2A glioma cells
and 2 administrations of saline or αPD-L1-LNP/Dina (2.5 mg/kg Dina) through the intracranial …