Objective: Piperacillin-tazobactam is a commonly used antibiotic in critically ill patients;
however, controversy exists as to whether mortality in serious infections can be decreased …

This review critically appraises the published microbiologic and clinical data on the treatment
of patients with carbapenem‐resistant Acinetobacter baumannii infections. Despite being …

Imipenem (IMI)/cilastatin/relebactam (REL) (I/R) is a novel β-lactam/β-lactamase inhibitor
combination with expanded microbiologic activity against carbapenem-resistant non-…

Vancomycin has been associated with acute kidney injury (AKI). However, the
pharmacokinetic/toxicodynamic relationship for AKI is not well defined. Allometrically scaled …

Purpose of Review Hospital-acquired and ventilator-associated pneumonia (VAP) are
frequent causes of infection among critically ill patients. VAP is the most common hospital-…

Urinary biomarkers are superior to serum creatinine for defining onset and extent of kidney
injury. This study classifies the temporal predictive ability of biomarkers for vancomycin-…

Vancomycin has been associated with acute kidney injury in preclinical and clinical settings;
however, the precise exposure profiles associated with vancomycin-induced acute kidney …

This phase I study evaluated the safety of the optimal ceftazidime-avibactam (CZA) with
aztreonam (ATM) regimens identified in hollow fiber infection models of MBL-producing …

Objectives To identify the pharmacokinetic (PK) and toxicodynamic (TD) relationship for
vancomycin-induced kidney injury. Methods Male Sprague–Dawley rats received intravenous (iv…

Multidrug resistance(MDR) among Pseudomonas aeruginosa (PSA) isolates presents a
significant clinical challenge and can substantially complicate the approach to selection of …