Inactivation of cell death is a major step in tumor development, and p53, a tumor suppressor
frequently mutated in cancer, is a critical mediator of cell death. While a role for p53 in …

Macroautophagy (hereafter referred to as autophagy) is a process in which organelles
termed autophagosomes deliver cytoplasmic constituents to lysosomes for degradation 1 . …

… We also thank Margaret O'Prey, David Strachan and Tom Gilbey (Beatson Institute) for
excellent technical assistance, Catherine Winchester (Beatson Institute) and members of the Tait …

It is now well established that tumours undergo changes in cellular metabolism 1. As this
can reveal tumour cell vulnerabilities and because many tumours exhibit enhanced glucose …

Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic material
in lysosomes. The process promotes cellular fidelity, and while the core machinery of …

Macroautophagy (autophagy) is intimately linked with cell death and allows cells to evade
apoptosis. This has prompted clinical trials to combine autophagy inhibitors with other drugs …

(Macro)autophagy delivers cellular constituents to lysosomes for degradation. Although a
cytoplasmic process, autophagy-deficient cells accumulate genomic damage, but an …

… 2 or 10 Gray Co 60 irradiation or 2 or 10 J/m 2 UV radiation. Cell lysates were prepared and
… the course of this work and to Professor J. Wyke, Professor D. Gillespie and Professor W. …

Background Imatinib and second-generation tyrosine kinase inhibitors (TKIs) nilotinib and
dasatinib have statistically significantly improved the life expectancy of chronic myeloid …

… effects of kaempferol, luteolin and apigenin on oral cells, whereas lipoxygenase pathways
mediate the growth-inhibitory effects of quercetin (J.O’Prey et al ., submitted for publication). …