Why have aggregative multicellular organisms stayed simple?

P Márquez-Zacarías, PL Conlin, K Tong, JT Pentz… - Current Genetics, 2021 - Springer
Multicellularity has evolved numerous times across the tree of life. One of the most fundamental
distinctions among multicellular organisms is their developmental mode: whether they …

[HTML][HTML] Experimental evolution of an alternating uni- and multicellular life cycle in Chlamydomonas reinhardtii

WC Ratcliff, MD Herron, K Howell, JT Pentz… - Nature …, 2013 - nature.com
The transition to multicellularity enabled the evolution of large, complex organisms, but early
steps in this transition remain poorly understood. Here we show that multicellular complexity…

[HTML][HTML] Killing by Type VI secretion drives genetic phase separation and correlates with increased cooperation

…, E Bernardy, J Thomas, A Kalziqi, J Pentz… - Nature …, 2017 - nature.com
By nature of their small size, dense growth and frequent need for extracellular metabolism,
microbes face persistent public goods dilemmas. Genetic assortment is the only general …

Interventions to promote oral medication adherence in the pediatric chronic illness population: a systematic review from the Children's Oncology Group

…, A Lloyd, L Petrando, J Pentz… - Journal of Pediatric …, 2019 - journals.sagepub.com
Pediatric oncology protocols frequently include multiple oral medications administered at
varied dosing schedules, often for prolonged periods of time. Nonadherence to protocol-…

Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law

…, SA Zamani-Dahaj, D Yanni, A Burnetti, J Pentz… - Elife, 2022 - elifesciences.org
The prevalence of multicellular organisms is due in part to their ability to form complex structures.
How cells pack in these structures is a fundamental biophysical issue, underlying their …

Cellular packing, mechanical stress and the evolution of multicellularity

S Jacobeen, JT Pentz, EC Graba, CG Brandys… - Nature physics, 2018 - nature.com
The evolution of multicellularity set the stage for sustained increases in organismal complexity
1 , 2 , 3 , 4 – 5 . However, a fundamental aspect of this transition remains largely unknown: …

[PDF][PDF] Ecological advantages and evolutionary limitations of aggregative multicellular development

JT Pentz, P Márquez-Zacarías, GO Bozdag, A Burnetti… - Current Biology, 2020 - cell.com
All multicellular organisms develop through one of two basic routes: they either aggregate
from free-living cells, creating potentially chimeric multicellular collectives, or they develop …

TEMPO AND MODE OF MULTICELLULAR ADAPTATION IN EXPERIMENTALLY EVOLVED SACCHAROMYCES CEREVISIAE

WC Ratcliff, JT Pentz, M Travisano - Evolution, 2013 - academic.oup.com
Multicellular complexity is a central topic in biology, but the evolutionary processes underlying
its origin are difficult to study and remain poorly understood. Here we use experimental …

Evolutionary consequences of nascent multicellular life cycles

JT Pentz, K MacGillivray, JG DuBose, PL Conlin… - Elife, 2023 - elifesciences.org
A key step in the evolutionary transition to multicellularity is the origin of multicellular groups
as biological individuals capable of adaptation. Comparative work, supported by theory, …

Physician pregnancy: male and female colleagues' attitudes.

…, KN Franco, SG Jurs, JE Pentz - Journal of the …, 1992 - europepmc.org
A survey questionnaire was mailed to residents and faculty at a midwestern medical school
to assess male and female attitudes toward colleagues' pregnancies. A total of 67%(N= 97) …