Knowledge of oncogenic mutations can inspire therapeutic strategies that are synthetically
lethal, affecting cancer cells while sparing normal cells. Lenalidomide is an active agent in …

… Tissue-Specific Nodes To identify tissue-specific network nodes, we compared the median
expression level ðe ðtÞ j Þ of a gene (j) in a particular tissue (t) to the median and IQR of its …

Sex differences manifest in many diseases and may drive sex-specific therapeutic responses.
To understand the molecular basis of sex differences, we evaluated sex-biased gene …

… between a SNP and a gene and 0 otherwise), k i is the degree of SNP i , d j is the degree
of gene j , and C i , C j are the community indexes of SNP i and gene j , respectively: …

Large systems of coupled oscillators subjected to a periodic external drive occur in many
situations in physics and biology. Here the simple paradigmatic case of equal strength, all-to-all …

Gene regulation plays a fundamental role in shaping tissue identity, function, and response
to perturbation. Regulatory processes are controlled by complex networks of interacting …

Inference and analysis of gene regulatory networks (GRNs) require software that integrates
multi-omic data from various sources. The Network Zoo (netZoo; netzoo.github.io) is a …

Genome Wide Association Studies (GWAS) and expression quantitative trait locus (eQTL)
analyses have identified genetic associations with a wide range of human phenotypes. …

Tuberculosis is the leading killer among infectious diseases worldwide. Increasing multidrug
resistance has prompted new approaches for tuberculosis drug development, including …

Background Cell lines are an indispensable tool in biomedical research and often used as
surrogates for tissues. Although there are recognized important cellular and transcriptomic …