The contribution of the nucleolus to cancer is well established with respect to its traditional
role in facilitating ribosome biogenesis and proliferative capacity. More contemporary studies …

Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation, …

The term “microbiota” invokes images of mucosal surfaces densely populated with bacteria.
These surfaces and the luminal compartments they form indeed predominantly harbor …

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing checkpoint …

CD8+ T cell recognition of peptide epitopes plays a central role in immune responses against
pathogens and tumors. However, the rules that govern which peptides are truly recognized …

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional
output, we used integrated epigenomic and transcriptomic analyses following acute …

Potassium ion homeostasis is essential for bacterial survival, playing roles in osmoregulation,
pH homeostasis, regulation of protein synthesis, enzyme activation, membrane potential …

Ribosome biogenesis and protein synthesis are dysregulated in many cancers, with those
driven by the proto-oncogene c-MYC characterized by elevated Pol I–mediated ribosomal …

The RNA polymerase II (POLII)–driven transcription cycle is tightly regulated at distinct
checkpoints by cyclin-dependent kinases (CDKs) and their cognate cyclins. The molecular events …

RNA polymerase I (Pol I)-mediated transcription of the ribosomal RNA genes (rDNA) is
confined to the nucleolus and is a rate-limiting step for cell growth and proliferation. Inhibition of …