User profiles for J. Säfholm

Jesper Säfholm

Assistant Professor, Karolinska Institutet
Verified email at safholm.com
Cited by 934

[HTML][HTML] Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing

…, TC Williams, A Ravindran, ÅK Björklund, J Säfholm… - Cell research, 2021 - nature.com
… Finally, we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,
revealing a subset of potentially immature ILCs with TCR-δ rearrangement. Our study provides a …

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69− CD56dim cells

…, MA Ivarsson, J Mjösberg, L Berglin, J Säfholm… - Journal of allergy and …, 2017 - Elsevier
Background In contrast to the extensive knowledge about human natural killer (NK) cells in
peripheral blood, relatively little is known about NK cells in the human lung. Knowledge …

[HTML][HTML] IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways

ML Manson, J Säfholm, A James, AK Johnsson… - Journal of Allergy and …, 2020 - Elsevier
Background Specific inflammatory pathways are indicated to contribute to severe asthma,
but their individual involvement in the development of airway hyperresponsiveness remains …

Prostaglandin E2 inhibits mast cell–dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor

J Säfholm, ML Manson, J Bood, I Delin, AC Orre… - Journal of Allergy and …, 2015 - Elsevier
Background Inhaled prostaglandin (PG) E 2 might inhibit asthmatic responses, but the
mechanisms involved remain undefined. Objective We sought to characterize the direct and …

The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea

V Pulkkinen, ML Manson, J Säfholm… - … of Physiology-Lung …, 2012 - journals.physiology.org
Activation of taste receptors (TAS2Rs) by bitter taste agonists has been reported to cause
bronchodilation. The aim of this study was to extend the information on the effects of bitter taste …

Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle

ML Manson, J Säfholm, M Al-Ameri, P Bergman… - European journal of …, 2014 - Elsevier
Taste-sensing type 2 receptors (TAS2Rs) have been implicated in extraoral functions.
Airway smooth muscle expresses TAS2Rs and is strongly relaxed by TAS2R agonists. We …

Lipid mediator quantification in isolated human and guinea pig airways: an expanded approach for respiratory research

J Kolmert, A Fauland, D Fuchs, J Säfholm… - Analytical …, 2018 - ACS Publications
The clinical importance of prostaglandins and leukotrienes in asthma is well recognized;
however, the biochemical role of other lipid mediators (often termed oxylipins) in the regulation …

[HTML][HTML] Immunoprofiling reveals novel mast cell receptors and the continuous nature of human lung mast cell heterogeneity

…, DZH Boey, A Ravindran, J Säfholm… - Frontiers in …, 2022 - frontiersin.org
Background Immunohistochemical analysis of granule-associated proteases has revealed
that human lung mast cells constitute a heterogeneous population of cells, with distinct …

PGE2 maintains the tone of the guinea pig trachea through a balance between activation of contractile EP1 receptors and relaxant EP2 receptors

J Säfholm, SE Dahlén, I Delin, K Maxey… - British journal of …, 2013 - Wiley Online Library
Background and Purpose The guinea pig trachea ( GPT ) is commonly used in airway
pharmacology. The aim of this study was to define the expression and function of EP receptors for …

[HTML][HTML] Divergent effects of acute and prolonged interleukin 33 exposure on mast cell IgE-mediated functions

…, C Ceriol, M Enoksson, M Arock, J Säfholm… - Frontiers in …, 2019 - frontiersin.org
Background: Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP),
have attracted interest because of their roles in chronic allergic inflammation-related …