Gene targeting in embryonic stem cells has become the principal technology for manipulation
of the mouse genome, offering unrivalled accuracy in allele design and access to …

We have developed a comprehensive gene orientated phylogenetic resource, EnsemblCompara
GeneTrees, based on a computational pipeline to handle clustering, multiple alignment…

Klebsiella pneumoniae is now recognized as an urgent threat to human health because of
the emergence of multidrug-resistant strains associated with hospital outbreaks and …

Long non-coding RNAs (lncRNAs) are largely heterogeneous and functionally uncharacterized.
Here, using FANTOM5 cap analysis of gene expression (CAGE) data, we integrate …

The Ensembl ( ) project provides a comprehensive and integrated source of annotation of
chordate genome sequences. Over the past year the number of genomes available from …

A systematic review and meta-analyses were performed to identify the risk factors associated
with carbapenem-resistant Pseudomonas aeruginosa and to identify sources and …

The FANTOM5 project investigates transcription initiation activities in more than 1,000 human
and mouse primary cells, cell lines and tissues using CAGE. Based on manual curation of …

Although it is generally accepted that cellular differentiation requires changes to transcriptional
networks, dynamic regulation of promoters and enhancers at specific sets of genes has …

MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As part
of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) project, …

With the use of an NMR-based method, potent (IC 50 < 25 nM) nonpeptide inhibitors of the
matrix metalloproteinase stromelysin (MMP-3) were discovered. The method, called SAR by …