User profiles for J. Shorenstein
 | Joshua ShorensteinSr Scientist, Inscripta Verified email at inscripta.com Cited by 1569 |
American gut: an open platform for citizen science microbiome research
…, A Robbins-Pianka, N Sangwan, J Shorenstein… - Msystems, 2018 - Am Soc Microbiol
Although much work has linked the human microbiome to specific phenotypes and lifestyle
variables, data from different projects have been challenging to integrate and the extent of …
variables, data from different projects have been challenging to integrate and the extent of …
Qiita: rapid, web-enabled microbiome meta-analysis
…, SB Orchanian, JG Sanders, J Shorenstein… - Nature …, 2018 - nature.com
Multi-omic insights into microbiome function and composition typically advance one study at
a time. However, in order for relationships across studies to be fully understood, data must …
a time. However, in order for relationships across studies to be fully understood, data must …
Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity
Q Ge, H Ilves, A Dallas, P Kumar, J Shorenstein… - Rna, 2010 - rnajournal.cshlp.org
Small hairpin RNAs (shRNAs) are widely used in RNAi studies and typically consist of a stem
of 19–29 base pairs (bp), a loop of at least 4 nucleotides (nt), and a dinucleotide overhang …
of 19–29 base pairs (bp), a loop of at least 4 nucleotides (nt), and a dinucleotide overhang …
Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs
Q Ge, A Dallas, H Ilves, J Shorenstein, MA Behlke… - Rna, 2010 - rnajournal.cshlp.org
Small hairpin RNAs (shRNAs) with 19-base-pair, or shorter, stems (short shRNAs [sshRNAs])
have been found to constitute a class whose mechanism of action appears to be distinct …
have been found to constitute a class whose mechanism of action appears to be distinct …
Metagenomic covariation along densely sampled environmental gradients in the Red Sea
Oceanic microbial diversity covaries with physicochemical parameters. Temperature, for
example, explains approximately half of global variation in surface taxonomic abundance. It is …
example, explains approximately half of global variation in surface taxonomic abundance. It is …
Right-and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
…, H Ilves, Q Ge, P Kumar, J Shorenstein… - Nucleic acids …, 2012 - academic.oup.com
Small hairpin RNAs (shRNAs) having duplex lengths of 25–29 bp are normally processed
by Dicer into short interfering RNAs (siRNAs) before incorporation into the RNA-induced …
by Dicer into short interfering RNAs (siRNAs) before incorporation into the RNA-induced …
Formulated minimal-length synthetic small hairpin RNAs are potent inhibitors of hepatitis C virus in mice with humanized livers
H Ma, A Dallas, H Ilves, J Shorenstein, I MacLachlan… - Gastroenterology, 2014 - Elsevier
… of interest The authors disclose the following: Han Ma and Klaus Klumpp are employees of
Hoffmann-La Roche, Inc; Brian Johnston, Anne Dallas, Heini Ilves, and Joshua Shorenstein …
Hoffmann-La Roche, Inc; Brian Johnston, Anne Dallas, Heini Ilves, and Joshua Shorenstein …
[HTML][HTML] Minimal-length synthetic shRNAs formulated with lipid nanoparticles are potent inhibitors of hepatitis C virus IRES-linked gene expression in mice
A Dallas, H Ilves, J Shorenstein, A Judge… - … Therapy-Nucleic Acids, 2013 - cell.com
We previously identified short synthetic shRNAs (sshRNAs) that target a conserved hepatitis
C virus (HCV) sequence within the internal ribosome entry site (IRES) of HCV and potently …
C virus (HCV) sequence within the internal ribosome entry site (IRES) of HCV and potently …
A framework for evaluating edited cell libraries created by massively parallel genome engineering
…, CD Sanada, TM Shaver, TR Shepherd, J Shorenstein… - bioRxiv, 2021 - biorxiv.org
Genome engineering methodologies are transforming biological research and discovery.
Approaches based on CRISPR technology have been broadly adopted and there is growing …
Approaches based on CRISPR technology have been broadly adopted and there is growing …
Loss of the Sigma Activity of RNA Polymerase of Bacillus subtilis during Sporulation
…, AL Greenleaf, RG Shorenstein… - Proceedings of the …, 1973 - National Acad Sciences
… One mechanism to explain the loss of the j' subunit (2) would be its conversion to the …
We thank J. Pero and AL Sonenshein for a critical reading of the manuscript, C. Goff and T. …
We thank J. Pero and AL Sonenshein for a critical reading of the manuscript, C. Goff and T. …