User profiles for J. Sidorenko
Julia SidorenkoVerified email at imb.uq.edu.au Cited by 9976 |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
…, AL Richards, J Sidorenko, Y Wu, J Zeng, J Grove… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
…, M Zacher, TA Nguyen-Viet, P Bowers, J Sidorenko… - Nature …, 2018 - nature.com
Here we conducted a large-scale genetic association analysis of educational attainment in
a sample of approximately 1.1 million individuals and identify 1,271 independent genome-…
a sample of approximately 1.1 million individuals and identify 1,271 independent genome-…
[HTML][HTML] Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
…, H Jayashankar, M Bennett, SM Nehzati, J Sidorenko… - Nature …, 2022 - nature.com
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome-wide-…
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome-wide-…
Meta-analysis of genome-wide association studies for height and body mass index in∼ 700000 individuals of European ancestry
Recent genome-wide association studies (GWAS) of height and body mass index (BMI) in ∼250000
European participants have led to the discovery of ∼700 and ∼100 nearly …
European participants have led to the discovery of ∼700 and ∼100 nearly …
[HTML][HTML] A saturated map of common genetic variants associated with human height
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50%
of phenotypic variation in human height, but identifying the specific variants and …
of phenotypic variation in human height, but identifying the specific variants and …
[HTML][HTML] Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes
Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a meta-analysis
of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 …
of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 …
[HTML][HTML] Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture
Genetic association studies have identified 44 common genome-wide significant risk loci for
late-onset Alzheimer’s disease (LOAD). However, LOAD genetic architecture and prediction …
late-onset Alzheimer’s disease (LOAD). However, LOAD genetic architecture and prediction …
[HTML][HTML] Improved polygenic prediction by Bayesian multiple regression on summary statistics
… focus on the full conditional distribution of β j under the proposed multiple regression model.
… The full conditional distribution of β j under this assumption (see Supplementary Note 3) is …
… The full conditional distribution of β j under this assumption (see Supplementary Note 3) is …
Signatures of negative selection in the genetic architecture of human complex traits
… where β j is the allelic substitution effect of an SNP j, p j is the MAF of the SNP, \({\sigma }_{\beta
}^{2}\) … The variance of β j when β j is nonzero, \({\sigma }_{j}^{2}={\left[2{p}_{j}\left(1-{p}_{…
}^{2}\) … The variance of β j when β j is nonzero, \({\sigma }_{j}^{2}={\left[2{p}_{j}\left(1-{p}_{…
[HTML][HTML] Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a
genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 …
genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 …