[PDF][PDF] The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations
…, J Stocksdale, MS Casale, TG Thompson, J Wu… - Cell systems, 2018 - cell.com
The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program that catalogs how human cells globally respond to chemical, genetic, and …
Fund program that catalogs how human cells globally respond to chemical, genetic, and …
[PDF][PDF] Mutant huntingtin disrupts the nuclear pore complex
…, J Ochaba, C Geater, E Morozko, J Stocksdale… - Neuron, 2017 - cell.com
Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT)
gene. The mechanism(s) by which mutant HTT (mHTT) causes disease is unclear. …
gene. The mechanism(s) by which mutant HTT (mHTT) causes disease is unclear. …
[PDF][PDF] Huntington's disease iPSC-derived brain microvascular endothelial cells reveal WNT-mediated angiogenic and blood-brain barrier deficits
Brain microvascular endothelial cells (BMECs) are an essential component of the blood-brain
barrier (BBB) that shields the brain against toxins and immune cells. While BBB …
barrier (BBB) that shields the brain against toxins and immune cells. While BBB …
[HTML][HTML] Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
…, J Roggenbuck, MB Harms, J Stocksdale… - Nature …, 2022 - nature.com
Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent
stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and …
stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and …
[HTML][HTML] A comparison of mRNA sequencing with random primed and 3′-directed libraries
…, J Bochicchio, L Lenaeus, J Stocksdale, J Shim… - Scientific reports, 2017 - nature.com
Creating a cDNA library for deep mRNA sequencing (mRNAseq) is generally done by
random priming, creating multiple sequencing fragments along each transcript. A 3′-end-focused …
random priming, creating multiple sequencing fragments along each transcript. A 3′-end-focused …
[PDF][PDF] An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
Neurodegenerative diseases are challenging for systems biology because of the lack of
reliable animal models or patient samples at early disease stages. Induced pluripotent stem …
reliable animal models or patient samples at early disease stages. Induced pluripotent stem …
Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-human ACE2 transgenic mice
…, J Wu, MS Burns, KI Tsourmas, J Stocksdale… - Journal of …, 2022 - Am Soc Microbiol
Unlike SARS-CoV-1 and MERS-CoV, infection with SARS-CoV-2, the viral pathogen
responsible for COVID-19, is often associated with neurologic symptoms that range from mild to …
responsible for COVID-19, is often associated with neurologic symptoms that range from mild to …
PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease
…, J Zaifman, A Hill, JT Stocksdale… - Proceedings of the …, 2021 - National Acad Sciences
DNA damage repair genes are modifiers of disease onset in Huntington’s disease (HD), but
how this process intersects with associated disease pathways remains unclear. Here we …
how this process intersects with associated disease pathways remains unclear. Here we …
[PDF][PDF] Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulation
Aberrant neuronal development and the persistence of mitotic cellular populations have
been implicated in a multitude of neurological disorders, including Huntington's disease (HD). …
been implicated in a multitude of neurological disorders, including Huntington's disease (HD). …
[HTML][HTML] Analysis of allele-specific RNA transcription in FSHD by RNA-DNA FISH in single myonuclei
…, R Tawil, LF Lock, JE Hewitt, J Stocksdale… - European Journal of …, 2010 - nature.com
Autosomal dominant facioscapulohumeral muscular dystrophy (FSHD) is likely caused by
epigenetic alterations in chromatin involving contraction of the D4Z4 repeat array near the …
epigenetic alterations in chromatin involving contraction of the D4Z4 repeat array near the …