Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan
parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan …

Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence,
disruption of essential protein kinase function has been explored for therapy of parasitic …

Toxoplasma gondii is a widely distributed protozoan pathogen that causes devastating
ocular and central nervous system disease. We show that the endochin-like quinolone (ELQ) …

The historical antimalarial compound endochin served as a structural lead for optimization.
Endochin-like quinolones (ELQ) were prepared by a novel chemical route and assessed for …

New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by
the protozoan parasite Toxoplasma gondii. To this end, we previously developed a potent …

This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of
One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared …

Human babesiosis is a tick-borne multisystem disease caused by Babesia species of the
apicomplexan phylum. Most clinical cases and fatalities of babesiosis are caused by Babesia …

We describe noncovalent, reversible asparagine ethylenediamine (AsnEDA) inhibitors of
the Plasmodium falciparum proteasome (Pf20S) β5 subunit that spare all active subunits of …

Toxoplasma gondii is a unicellular parasite that causes severe brain and eye disease.
Current drugs for T. gondii are limited by toxicity. Bumped kinase inhibitors (BKIs) selectively …

Objectives: To determine whether cystic neutrophilic granulomatous mastitis (CNGM) can
be associated with Gram-positive bacilli and Corynebacterium Methods: We reviewed our …