The genus Enterovirus (EV) of the family Picornaviridae includes poliovirus, coxsackieviruses,
echoviruses, numbered enteroviruses and rhinoviruses. These diverse viruses cause a …

The secretory pathway is of vital importance for eukaryotic cells and has a pivotal role in the
synthesis, sorting, processing and secretion of a large variety of bioactive molecules …

Positive-strand (+) RNA viruses are important and emerging pathogens of humans, animals,
and plants. Upon infection, they induce the formation of specialized membranous …

Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this
study, we identify ITZ as a broad-spectrum inhibitor of enteroviruses (eg, poliovirus, …

RNA viruses can rapidly mutate and acquire resistance to drugs that directly target viral
enzymes, which poses serious problems in a clinical context. Therefore, there is a growing …

… Cytotoxicity of AL-9 was determined in a cell viability assay run in parallel (J). Bars represent
mean values of triplicates ± standard error of the means (SEM). Means were statistically …

All viruses that carry a positive-sense RNA genome (+RNA), such as picornaviruses,
hepatitis C virus, dengue virus, and SARS- and MERS-coronavirus, confiscate intracellular …

… (j) Late-stage VRCs of coxsackievirus B3 showing double-membrane vesicles (orange)
and multilamellar vesicles (red). C has been reprinted from Ref. [79] with permission from …

Highlights • Enteroviruses cause many human diseases, yet no antiviral drugs are available.
• Capsids and viral enzymes are promising targets for direct-acting antiviral therapy. • …

Enteroviruses, eg, polio-, coxsackie- and rhinoviruses, constitute a large genus within the
Picornaviridae family of positive-strand RNA viruses and include many important pathogens …