The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …

Inflammasome activation leads to caspase-1 activation, which causes the maturation and
secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR (…

NLR (nucleotide-binding domain, leucine-rich repeat–containing) proteins have rapidly
emerged as central regulators of immunity and inflammation with demonstrated relevance to …

Immune regulatory proteins such as CIITA, NAIP, IPAF, NOD1, NOD2, NALP1, and cryopyrin
(also known as NALP3) are members of a family characterized by the presence of a NACHT …

Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We
aim to establish clinically relevant molecular subtypes that would encompass this …

NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that
detects a broad range of microbial motifs, endogenous danger signals and environmental …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2
diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by …

The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition
molecules mediate host immunity to various pathogenic stimuli. However, in vivo …

… Ting … Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes Brain Behav. 7, 152–163
(… Christopher for advice and assistance with electron microscopy techniques; J. Crawley for …