Schistosoma mansoni is the parasite responsible for schistosomiasis, a disease that affects
about 218 million people worldwide. Currently, both direct treatment and disease control …

Schistosoma mansoni depends upon the purine salvage pathway to obtain purine
nucleotides; therefore, enzymes from this pathway are essential for parasite survival. Here, we …

Schistosoma mansoni, the parasite responsible for schistosomiasis, lacks the “de novo” purine
biosynthetic pathway and depends entirely on the purine salvage pathway for the supply …

Purine nucleoside phosphorylases (PNPs) play an important role in the blood fluke parasite
Schistosoma mansoni as a key enzyme of the purine salvage pathway. Here we present the …

Schistosomiasis is a parasitic infection caused by trematode worms (also called blood flukes)
of the genus Schistosoma sp., which affects over 230 million people worldwide, causing …

Norberto, Matheus S., João Victor G. Torini, Matheus S. Firmino, and Marcelo Papoti.
Validation of air storage system for hypoxia exposure during exercise. High Alt Med Biol. 00:000–…

Schistosoma mansoni do not have de novo purine pathways and rely on purine salvage for
their purine supply. It has been demonstrated that, unlike humans, the S. mansoni is able to …

Schistosomiasis, caused by Schistosoma mansoni trematode worm, affects more than 1.5
million people in Brazil. The current treatment consists in the administration of Praziquantel, …

The parasite Schistosoma mansoni possess all pathways for pyrimidine biosynthesis, whereby
deaminases play an essential role in the thymidylate cycle, a crucial step to controlling …

Nucleoside diphosphate kinases (NDPKs) are crucial to keep the high triphosphate
nucleotide levels in the biological process. The enzymatic mechanism has been extensively …