Chemokines – chemotactic cytokines – are small secreted proteins that attract and activate
immune and non-immune cells in vitro and in vivo. It has been suggested that chemokines …

… Juliette Van Steenwinckel … Juliette Van Steenwinckel … in central nerve endings in small
clear and dense core vesicles (Van Steenwinckel et al. 2011), where they co-localize with …

Perinatal insults are a leading cause of infant mortality and amongst survivors are frequently
associated with neurocognitive impairment, cerebral palsy (CP), and seizure disorders. The …

CCL2 chemokine and its receptor CCR2 may contribute to neuropathic pain development.
We tested the hypothesis that injury to peripheral nerves triggers CCL2 release from afferents …

Objective To investigate the effects of melatonin treatment in a rat model of white matter
damage (WMD) in the developing brain. Additionally, we aim to delineate the cellular …

Oligodendrocyte precursor cells (OPCs) constitute the main proliferative cells in the adult
brain, and deregulation of OPC proliferation-differentiation balance results in either glioma …

Microglia of the developing brain have unique functional properties but how their activation
states are regulated is poorly understood. Inflammatory activation of microglia in the still-…

Traumatic brain injury (TBI) results in white matter injury (WMI) that is associated with
neurological deficits. Neuroinflammation originating from microglial activation may participate in …

The identification of drug targets is highly challenging, particularly for diseases of the brain.
To address this problem, we developed and experimentally validated a general …

Preterm birth places infants in an adverse environment that leads to abnormal brain
development and cerebral injury through a poorly understood mechanism known to involve …