Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26
(HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe …

We report a 100-million atom-scale model of an entire cell organelle, a photosynthetic
chromatophore vesicle from a purple bacterium, that reveals the cascade of energy conversion …

Single particle analysis cryo-electron microscopy (EM) and molecular dynamics (MD) have
been complimentary methods since cryo-EM was first applied to the field of structural biology. …

Breast cancer starts as a local disease, but it can metastasize to the lymph nodes and distant
organs. At primary diagnosis, prognostic markers are used to assess whether the transition …

Cryoelectron microscopy requires molecular modeling for refinement of structures. Ensemble
models arrive at low free-energy molecular structures, but are computationally expensive …

Nitric oxide (NO) is a free radical which has important effects on bone cell function. The
endothelial isoform of nitric oxide synthase (eNOS) is widely expressed in bone on a constitutive …

Despite significant advances in resolution, the potential for cryo-electron microscopy (EM) to
be used in determining the structures of protein–drug complexes remains unrealized. …

Breast cancer patients with the same stage of disease can have markedly different treatment
responses and overall outcome. The strongest predictors for metastases (for example, …

Background A more accurate means of prognostication in breast cancer will improve the
selection of patients for adjuvant systemic therapy. Methods Using microarray analysis to …

Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue"
disease subtypes. However, the extent to which genomic signatures are shared across tissues …