By interacting specifically with proteins, phosphoinositides organize the spatiotemporal
formation of protein complexes involved in the control of intracellular signaling, vesicular …

Blood platelets are produced by megakaryocytes through a complex program of differentiation
and play a critical role in hemostasis and thrombosis. These anucleate cells are the target …

… Pak1 (in pJ3) and myc-tagged Cdc42 (in pCMV6M) were generously provided by J. Chernoff.
… Turk and J. Chernoff for comments on the manuscript and the FCCC Organic Synthesis …

Phosphoinositides play a central role in many physiological processes by assisting the
recruitment of proteins to membranes through specific phosphoinositide-binding motifs. How this …

… The effects on F-actin stress fibers loss were also observed following addition of
exogenous PtdIns5P but not by PtdIns3P or PtdIns4P (J. Viaud & F. Gaits-Iacovoni, personal …

Small molecules that produce nonfunctional protein–protein complexes are an alternative to
competitive inhibitors for the inhibition of protein functions. Here we target the activation of …

PtdIns5P is a lipid messenger acting as a stress-response mediator in the nucleus, and
known to maintain cell activation through traffic alterations upon bacterial infection. Here, we …

… We denote j δ x j ′ , with x minimal element in the lattice for … basis, with a rule X + j ′ → j for
each j δ X j ′ (see section 2.3). … J L by j Δ j ′ if there exists x ∈ S such that j < j ′ ∨ x and j …

… Image sequences of the time-lapse recording and surface coverage were analyzed using
Image J … Senis YA, Mazharian A, Mori J. Src family kinases: at the forefront of platelet activation. …

Essentials • Information about the formation of the demarcation membrane system (DMS) is
still lacking. • We investigated the role of the cytoskeleton in DMS structuration in …