The retinoblastoma gene was identified over a decade ago as the first tumor suppressor.
Although the gene was initially cloned as a result of its frequent mutation in the rare pediatric …

Metastasis is a defining feature of malignant tumors and is the most common cause of
cancer-related death, yet the genetics of metastasis are poorly understood. We used exome …

We present evidence that phosphorylation of the C-terminal region of Rb by Cdk4/6 initiates
successive intramolecular interactions between the C-terminal region and the central pocket…

Small cell lung cancer (SCLC) has been associated with loss of heterozygosity at several
distinct genetic loci including chromosomes 3p, 13q, and 17p. To determine whether the …

Melanomas are notoriously difficult to classify because of a lack of discrete clinical and
pathological stages. Here, we show that primary uveal melanomas surprisingly cluster into two …

We present evidence that Rb forms a repressor containing histone deacetylase (HDAC) and
the hSWI/SNF nucleosome remodeling complex, which inhibits transcription of genes for …

PURPOSE: This study evaluates the prognostic performance of a 15 gene expression profiling
(GEP) assay that assigns primary posterior uveal melanomas to prognostic subgroups: …

Loss of cell-cycle control is a hallmark of neoplastic cells. One regulator of the critical G1 to S-phase
transition in the cell cycle is the retinoblastoma tumour suppressor protein Rb, which …

Uveal melanoma is the most common primary cancer of the eye and often results in fatal
metastasis. Here, we describe mutations occurring exclusively at codon 625 of the SF3B1 gene, …

Purpose To evaluate the surgical results in a series of patients with diabetic macular edema
associated with traction from a thickened and taut posterior hyaloid membrane and to …