The discovery and design of biologically important RNA molecules is outpacing three-dimensional
structural characterization. Here, we demonstrate that cryo-electron microscopy can …

We introduce a toolset of program libraries collectively titled multipurpose atom‐typer for
CHARMM (MATCH) for the automated assignment of atom types and force field parameters for …

RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of
RNA 3D structure prediction. With agreement from crystallographers, the RNA structures are …

S-Adenosylmethionine (AdoMet)-based methylation is integral to metabolism and signaling.
AdoMet-dependent methyltransferases belong to multiple distinct classes and share a …

RNAs fold into defined tertiary structures to function in critical biological processes. While
quantitative models can predict RNA secondary structure stability, we are still unable to predict …

RNA nanotechnology seeks to create nanoscale machines by repurposing natural RNA
modules. The field is slowed by the current need for human intuition during three-dimensional …

Biomolecules form dynamic ensembles of many inter-converting conformations which are
key for understanding how they fold and function. However, determining ensembles is …

… j Cumulative distribution of the minimal distances between the two arms of each read for
reads mapped to different types of structures. Only non-dsRNA, or tertiary contact, reads are …

Despite the critical roles RNA structures play in regulating gene expression, sequencing-based
methods for experimentally determining RNA base pairs have remained inaccurate. Here…

SET domain lysine methyltransferases (KMTs) are S-adenosylmethionine (AdoMet)-dependent
enzymes that catalyze the site-specific methylation of lysyl residues in histone and non-…