Respiratory chain complexes assemble into functional quaternary structures called
supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae. Here, we …

The textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving
entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This …

Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Human mitochondrial DNA (mtDNA) shows extensive within-population sequence variability
1 . Many studies suggest that mtDNA variants may be associated with ageing or diseases 2 …

Common mitochondrial DNA (mtDNA) haplotypes in humans and mice have been associated
with various phenotypes, including learning performance and disease penetrance. Notably…

Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem
cells (satellite cells), a process that becomes less efficient with aging. Here, we show that …

Increased production of reactive oxygen species (ROS) has long been considered a cause
of aging. However, recent studies have implicated ROS as essential secondary messengers. …

Expansion of human stem cells before cell therapy is typically performed at 20% O 2. Growth
in these pro-oxidative conditions can lead to oxidative stress and genetic instability. Here, …

Mitochondria are dynamic subcellular organelles that convert nutrient intermediates into
readily available energy equivalents. Optimal mitochondrial function is ensured by a highly …

Reactive oxygen species (ROS) are series of chemical products originated from one or several
electron reductions of oxygen. ROS are involved in physiology and disease and can also …