Over 30 years ago, receptors for the Fc region of IgG (FcγR) were implicated in the pathogenesis
of systemic lupus erythematosus (SLE). Since those pioneering studies, our knowledge …

Genome-wide association studies have recently identified at least 15 susceptibility loci for
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from …

A novel polymorphism in the extracellular domain 2 (EC2) of FcgammaRIIIA affects ligand
binding by natural killer (NK) cells and monocytes from genotyped homozygous normal …

Family studies of first-degree relatives and analysis of twins indicate that as much as 75% of
the differences in quantitative IL-10 production in man derive from heritable genetic factors. …

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using Immunochip …

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry
genetic research of RA promises to improve power to detect genetic signals, fine-…

Fc receptors represent a distinct group of hematopoeitic cell surface glycoproteins that have
a characterized role in affecting the efficiency of the mononuclear phagocyte system to clear …

Aberrant glycosylation of IgA1 plays an essential role in the pathogenesis of IgA nephropathy.
This abnormality is manifested by a deficiency of galactose in the hinge-region O-linked …

Two different allelic polymorphisms among the isoforms of human Fc gamma receptors have
been defined: the low-responder (LR)-high-responder (HR) polymorphism of huFc gamma …

Systemic lupus erythematosus (SLE, MIM152700) is an autoimmune disease characterized
by self-reactive antibodies resulting in systemic inflammation and organ failure. TNFAIP3, …