The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory
JD Sweatt - Journal of neurochemistry, 2001 - Wiley Online Library
The neuronal MAP kinase cascade: a biochemical signal integration system subserving
synaptic plasticity and memory - Sweatt - 2001 - Journal of Neurochemistry - Wiley Online …
synaptic plasticity and memory - Sweatt - 2001 - Journal of Neurochemistry - Wiley Online …
Mitogen-activated protein kinases in synaptic plasticity and memory
JD Sweatt - Current opinion in neurobiology, 2004 - Elsevier
This review highlights five areas of recent discovery concerning the role of extracellular-signal
regulated kinases (ERKs) in the hippocampus. First, ERKs have recently been directly …
regulated kinases (ERKs) in the hippocampus. First, ERKs have recently been directly …
Epigenetic mechanisms in memory formation
JM Levenson, JD Sweatt - Nature Reviews Neuroscience, 2005 - nature.com
Discoveries concerning the molecular mechanisms of cell differentiation and development
have dictated the definition of a new sub-discipline of genetics known as epigenetics. …
have dictated the definition of a new sub-discipline of genetics known as epigenetics. …
[HTML][HTML] A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation
JD English, JD Sweatt - Journal of Biological Chemistry, 1997 - ASBMB
The mitogen-activated protein kinase (MAPK) cascade has been intensely studied as a primary
biochemical pathway through which a variety of extracellular stimuli initiate and regulate …
biochemical pathway through which a variety of extracellular stimuli initiate and regulate …
Lasting epigenetic influence of early-life adversity on the BDNF gene
BACKGROUND: Childhood maltreatment and early trauma leave lasting imprints on neural
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a caregiver…
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a caregiver…
[PDF][PDF] Covalent modification of DNA regulates memory formation
CA Miller, JD Sweatt - Neuron, 2007 - cell.com
DNA methylation is a covalent chemical modification of DNA catalyzed by DNA methyltransferases
(DNMTs). DNA methylation is associated with transcriptional silencing and has been …
(DNMTs). DNA methylation is associated with transcriptional silencing and has been …
The MAPK cascade is required for mammalian associative learning
…, JC Selcher, JJ Petraitis, JM Trzaskos, JD Sweatt - Nature …, 1998 - nature.com
… 44) and CREB (ref 45 and ED Roberson and JD English, personal communication). All of
these substrates could be targeted by MAPK during learning; future experiments studying …
these substrates could be targeted by MAPK during learning; future experiments studying …
[HTML][HTML] Regulation of histone acetylation during memory formation in the hippocampus
…, KD Brown, MA Trinh, DL Molfese, JD Sweatt - Journal of Biological …, 2004 - ASBMB
Formation of long term memory begins with the activation of many disparate signaling
pathways that ultimately impinge on the cellular mechanisms regulating gene expression. We …
pathways that ultimately impinge on the cellular mechanisms regulating gene expression. We …
[HTML][HTML] Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation
JD English, JD Sweatt - Journal of Biological Chemistry, 1996 - ASBMB
Although classically studied as regulators of cell proliferation and differentiation, mitogen-activated
protein kinases (MAPKs) are highly expressed in post-mitotic neurons of the adult …
protein kinases (MAPKs) are highly expressed in post-mitotic neurons of the adult …
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
…, Y Zhou, SL Campbell, T Le, E Li, JD Sweatt… - Nature …, 2010 - nature.com
Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …