User profiles for J.E. Castillo-Fernandez

Juan Edgar Castillo Fernández

Babraham Institute
Verified email at babraham.ac.uk
Cited by 1893

[HTML][HTML] A DNA methylation biomarker of alcohol consumption

…, AG Uitterlinden, I Yet, JE Castillo-Fernandez… - Molecular …, 2018 - nature.com
The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and
treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may …

[HTML][HTML] Epigenetics of discordant monozygotic twins: implications for disease

JE Castillo-Fernandez, TD Spector, JT Bell - Genome medicine, 2014 - Springer
Monozygotic (MZ) twins share nearly all of their genetic variants and many similar environments
before and after birth. However, they can also show phenotypic discordance for a wide …

[HTML][HTML] Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

…, MN Eliot, S Bollepalli, I Yet, JE Castillo-Fernandez… - Clinical …, 2018 - Springer
Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular
disease and diabetes. Many smoking-associated signals have been detected in the blood …

[HTML][HTML] Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects

C Christiansen, JE Castillo-Fernandez… - Clinical …, 2021 - Springer
Background Smoking remains one of the leading preventable causes of death. Smoking
leaves a strong signature on the blood methylome as shown in multiple studies using the …

[HTML][HTML] Identical twins carry a persistent epigenetic signature of early genome programming

…, K Sugden, S Lundgren, JE Castillo-Fernandez… - Nature …, 2021 - nature.com
Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-implantation
stages of development. The mechanisms underpinning this event have remained …

[HTML][HTML] Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

…, G Fiorito, J Huang, JE Castillo-Fernandez… - Nature …, 2021 - nature.com
Coffee and tea are extensively consumed beverages worldwide which have received
considerable attention regarding health. Intake of these beverages is consistently linked to, among …

[HTML][HTML] Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 …

…, R Joehanes, J Brody, JE Castillo-Fernandez… - The American journal of …, 2019 - Elsevier
Background Folate and vitamin B-12 are essential micronutrients involved in the donation of
methyl groups in cellular metabolism. However, associations between intake of these …

[HTML][HTML] Dissecting the role of the gut microbiota and diet on visceral fat mass accumulation

CI Le Roy, RCE Bowyer, JE Castillo-Fernandez… - Scientific reports, 2019 - nature.com
Both gut microbiota and diet have been shown to impact visceral fat mass (VFM), a major
risk factor for cardiometabolic disease, but their relative contribution has not been well …

Epigenome‐wide association of DNA methylation in whole blood with bone mineral density

…, V Forgetta, JE CastilloFernandez… - Journal of Bone and …, 2017 - academic.oup.com
Genetic and environmental determinants of skeletal phenotypes such as bone mineral
density (BMD) may converge through the epigenome, providing a tool to better understand …

[HTML][HTML] DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation

JE Castillo-Fernandez, YJ Loke, S Bass-Stringer… - Genome Medicine, 2017 - Springer
Background The association of in vitro fertilisation (IVF) and DNA methylation has been studied
predominantly at regulatory regions of imprinted genes and at just thousands of the ~28 …