User profiles for J.E. Castillo-Fernandez
Juan Edgar Castillo FernándezBabraham Institute Verified email at babraham.ac.uk Cited by 1893 |
[HTML][HTML] A DNA methylation biomarker of alcohol consumption
…, AG Uitterlinden, I Yet, JE Castillo-Fernandez… - Molecular …, 2018 - nature.com
The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and
treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may …
treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may …
[HTML][HTML] Epigenetics of discordant monozygotic twins: implications for disease
Monozygotic (MZ) twins share nearly all of their genetic variants and many similar environments
before and after birth. However, they can also show phenotypic discordance for a wide …
before and after birth. However, they can also show phenotypic discordance for a wide …
[HTML][HTML] Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health
Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular
disease and diabetes. Many smoking-associated signals have been detected in the blood …
disease and diabetes. Many smoking-associated signals have been detected in the blood …
[HTML][HTML] Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects
C Christiansen, JE Castillo-Fernandez… - Clinical …, 2021 - Springer
Background Smoking remains one of the leading preventable causes of death. Smoking
leaves a strong signature on the blood methylome as shown in multiple studies using the …
leaves a strong signature on the blood methylome as shown in multiple studies using the …
[HTML][HTML] Identical twins carry a persistent epigenetic signature of early genome programming
…, K Sugden, S Lundgren, JE Castillo-Fernandez… - Nature …, 2021 - nature.com
Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-implantation
stages of development. The mechanisms underpinning this event have remained …
stages of development. The mechanisms underpinning this event have remained …
[HTML][HTML] Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
Coffee and tea are extensively consumed beverages worldwide which have received
considerable attention regarding health. Intake of these beverages is consistently linked to, among …
considerable attention regarding health. Intake of these beverages is consistently linked to, among …
[HTML][HTML] Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 …
Background Folate and vitamin B-12 are essential micronutrients involved in the donation of
methyl groups in cellular metabolism. However, associations between intake of these …
methyl groups in cellular metabolism. However, associations between intake of these …
[HTML][HTML] Dissecting the role of the gut microbiota and diet on visceral fat mass accumulation
CI Le Roy, RCE Bowyer, JE Castillo-Fernandez… - Scientific reports, 2019 - nature.com
Both gut microbiota and diet have been shown to impact visceral fat mass (VFM), a major
risk factor for cardiometabolic disease, but their relative contribution has not been well …
risk factor for cardiometabolic disease, but their relative contribution has not been well …
Epigenome‐wide association of DNA methylation in whole blood with bone mineral density
…, V Forgetta, JE Castillo‐Fernandez… - Journal of Bone and …, 2017 - academic.oup.com
Genetic and environmental determinants of skeletal phenotypes such as bone mineral
density (BMD) may converge through the epigenome, providing a tool to better understand …
density (BMD) may converge through the epigenome, providing a tool to better understand …
[HTML][HTML] DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation
Background The association of in vitro fertilisation (IVF) and DNA methylation has been studied
predominantly at regulatory regions of imprinted genes and at just thousands of the ~28 …
predominantly at regulatory regions of imprinted genes and at just thousands of the ~28 …