Mapping AML heterogeneity-multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responses

JF Severens, EO Karakaslar, BA van der Reijden… - Leukemia, 2024 - nature.com
Subtyping of acute myeloid leukaemia (AML) is predominantly based on recurrent genetic
abnormalities, but recent literature indicates that transcriptomic phenotyping holds immense …

Single-cell analysis reveals cellular heterogeneity and molecular determinants of hypothalamic leptin-receptor cells

N Kakava-Georgiadou, JF Severens, AM Jørgensen… - bioRxiv, 2020 - biorxiv.org
Hypothalamic nuclei which regulate homeostatic functions express leptin receptor (LepR), the
primary target of the satiety hormone leptin. Single-cell RNA sequencing (scRNA-seq) has …

Precision and accuracy in measuring absence from work as a basis for calculating productivity costs in The Netherlands

JL Severens, J Mulder, RJF Laheij… - Social science & …, 2000 - Elsevier
The impact of disease on the ability of a person to perform work should be part of an economic
evaluation when a societal viewpoint is used for the analysis. This impact is reflected by …

Single step links of the superdeformed band in 194Pb: a measure of the absolute excitation energy, spin and parity of the superdeformed states

…, O Stezowski, C Theisen, U Van Severen… - Physics Letters B, 1996 - Elsevier
The EUROGAM array has been used to investigate the decay out of the yrast superdeformed
(SD) band in 194 Pb. Six single step decays from the lowest observed SD states to low-…

Cognitive behaviour therapy for chronic fatigue syndrome: a multicentre randomised controlled trial

…, E Bazelmans, LD Elving, TM de Boo, JL Severens… - The Lancet, 2001 - thelancet.com
… Johan Severens contributed to study design and editing of the paper. Gert-Jan van der
Wilt contributed to the study design and data analysis. Philip Spinhoven contributed to study …

[PDF][PDF] Cost of endoscopy in economic evaluation

RJF Laheij, JL Severens - 1997 - repository.ubn.ru.nl
… We read with interest the comments by Laheij and Severens. Although we agree with
their overall comments, several of their statements require clarification and explanation. …

The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis

…, GJ Jager, S Strum, YL Hoogeveen, JL Severens… - Clinical radiology, 2008 - Elsevier
AIM: To compare the diagnostic accuracy of computed tomography (CT) and magnetic
resonance imaging (MRI) in the diagnosis of lymph node metastases in prostate cancer. …

[HTML][HTML] Decoding sensorimotor rhythms during robotic-assisted treadmill walking for brain computer interface (BCI) applications

E García-Cossio, M Severens, B Nienhuis, J Duysens… - PloS one, 2015 - journals.plos.org
Locomotor malfunction represents a major problem in some neurological disorders like
stroke and spinal cord injury. Robot-assisted walking devices have been used during …

Transferability of economic evaluations across jurisdictions: ISPOR Good Research Practices Task Force report

…, F Malik, SD Reed, F Rutten, M Sculpher, J Severens - Value in health, 2009 - Elsevier
A growing number of jurisdictions now request economic data in support of their decision-making
procedures for the pricing and/or reimbursement of health technologies. Because more …

Socio-economic consequences of rheumatoid arthritis in the first years of the disease.

…, MA Van't Hof, AM Van Gestel, JL Severens - …, 1999 - academic.oup.com
OBJECTIVE: Few data have been presented to document the impact of rheumatoid arthritis (RA)
on socio-economic well-being. In this study, exact figures on socio-economic …