Gonadotropin-releasing hormone (GnRH) is a major regulator of reproduction through actions
on pituitary gonadotropin release and synthesis. Although it is often thought that pituitary …

Within eukaryotic cells, biochemical reactions need to be organized on the surface of membrane
compartments that use distinct lipid constituents to dynamically modulate the functions …

Among the structural phospholipids that form the bulk of eukaryotic cell membranes,
phosphatidylinositol (PtdIns) is unique in that it also serves as the common precursor for low‐…

… JG Pemberton would like to dedicate this article to his father, the late Dr. S. George Pemberton
(University of Alberta, Canada), whose insightful scientific discussions, mentorship, and …

Objective Intracellular signaling networks rely on proper membrane organization to control
an array of cellular processes such as metabolism, proliferation, apoptosis, and …

Phosphoinositide lipids (PPIn) are enriched in stearic‐ and arachidonic acids (38:4) but how
this enrichment is established and maintained during phospholipase C (PLC) activation is …

The lipid kinase PI 4 KB , which generates phosphatidylinositol 4‐phosphate ( PI 4P), is a key
enzyme in regulating membrane transport and is also hijacked by multiple picornaviruses …

Relative to mammals, the neuroendocrine control of pituitary growth hormone (GH) secretion
and synthesis in teleost fish involves numerous stimulatory and inhibitory regulators, many …

Stress in vertebrates is mediated by the hypothalamus-pituitary-adrenal (in mammals)/interrenal
(in fish) (HPA/I) axis, which produces the corticotropin-releasing factor (CRF), …

Phosphatidylinositol (PI) is the precursor lipid for the minor phosphoinositides (PPIns),
which are critical for multiple functions in all eukaryotic cells. It is poorly understood how …