Heart failure is a world-wide public health problem that affects 4.5 million patients in the
United States, necessitates one million hospitalizations each year, and causes 300,000 …

Congenital heart disease (CHD) is the most common congenital anomaly in newborn babies.
Cardiac malformations have been produced in multiple experimental animal models, by …

… SEIDMAN MD… Seidman received honoraria for CV grand rounds on the genetics in
HCM. … CE and JG Seidman co-own a patent for gene-based diagnosis of HCM. …

Holt-Oram syndrome is characterized by upper limb malformations and cardiac septation
defects. Here, we demonstrate that mutations in the human TBX5 gene underlie this disorder. …

Mutations in the gene encoding the homeobox transcription factor NKX2-5 were found to
cause nonsyndromic, human congenital heart disease. A dominant disease locus associated …

<p id="p001">Immune checkpoint inhibitors have improved clinical outcomes associated with
numerous cancers, but high-grade, immune-related adverse events can occur, particularly …

Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and therapeutic strategies require a deeper understanding of the …

Results The a and p cardiac MHC genes are only 4.5 kb apart (Saez et al., 1987; Matsuoka
et al., 1989). Each gene consists of 40 exons and encompasses approximately 30 kb of DNA. …

Background Inherited mutations cause approximately 35 percent of cases of dilated
cardiomyopathy; however, few genes associated with this disease have been identified. Previously, …

Background Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations
in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently …