Emerging oomycete threats to plants and animals

…, JC De la Concepcion… - … of the Royal …, 2016 - royalsocietypublishing.org
Oomycetes, or water moulds, are fungal-like organisms phylogenetically related to algae.
They cause devastating diseases in both plants and animals. Here, we describe seven …

[HTML][HTML] A molecular roadmap to the plant immune system

AR Bentham, JC De la Concepcion, N Mukhi… - Journal of Biological …, 2020 - ASBMB
Plant diseases caused by pathogens and pests are a constant threat to global food security.
Direct crop losses and the measures used to control disease (eg application of pesticides) …

[HTML][HTML] Pathways to engineering plant intracellular NLR immune receptors

R Zdrzałek, C Stone, JC De la Concepcion… - Current Opinion in Plant …, 2023 - Elsevier
Factors including climate change and increased global exchange are set to escalate the
prevalence of plant diseases, posing an unprecedented threat to global food security and …

ATG8 expansion: a driver of selective autophagy diversification?

R Kellner, JC De la Concepcion, A Maqbool… - Trends in plant …, 2017 - cell.com
Selective autophagy is a conserved homeostatic pathway that involves engulfment of
specific cargo molecules into specialized organelles called autophagosomes. The ubiquitin-like …

Lessons in effector and NLR biology of plant-microbe systems

…, EK Zess, JC De la Concepcion… - Molecular Plant …, 2018 - Am Phytopath Society
A diversity of plant-associated organisms secrete effectors—proteins and metabolites that
modulate plant physiology to favor host infection and colonization. However, effectors can also …

Polymorphic residues in rice NLRs expand binding and response to effectors of the blast pathogen

JC De la Concepcion, M Franceschetti, A Maqbool… - Nature plants, 2018 - nature.com
Accelerated adaptive evolution is a hallmark of plant–pathogen interactions. Plant
intracellular immune receptors (NLRs) often occur as allelic series with differential pathogen …

Protein engineering expands the effector recognition profile of a rice NLR immune receptor

JC De la Concepcion, M Franceschetti, D MacLean… - elife, 2019 - elifesciences.org
… The wild-type Pikp-HMA, Pikm-HMA, and AVR-Pik expression constructs used in this study
are as described in De la Concepcion et al. (2018). For Y2H, we cloned Pikp-HMANK-KE (as …

Effector target-guided engineering of an integrated domain expands the disease resistance profile of a rice NLR immune receptor

…, A Longya, CEM Stevenson, JC De la Concepcion… - Elife, 2023 - elifesciences.org
A subset of plant intracellular NLR immune receptors detect effector proteins, secreted by
phytopathogens to promote infection, through unconventional integrated domains which …

Nine things to know about elicitins

L Derevnina, YF Dagdas, JC De la Concepcion… - New …, 2016 - Wiley Online Library
… Juan Carlos De la Concepcion … Juan Carlos De la Concepcion … infestans infection
on one Désirée-ELR transformant and the Désirée control at 6 d post-inoculation. …

A blast fungus zinc-finger fold effector binds to a hydrophobic pocket in host Exo70 proteins to modulate immune recognition in rice

JC De la Concepcion, K Fujisaki… - Proceedings of the …, 2022 - National Acad Sciences
Exocytosis plays an important role in plant–microbe interactions, in both pathogenesis and
symbiosis. Exo70 proteins are integral components of the exocyst, an octameric complex that …