… Figure panels are taken or modified from Westhoff et al. (93), Wittbrodt et al. (125), Pandey
… Copyright © 2018 Gehrig, Pandey and Westhoff. This is an open-access article distributed …

There is increasing evidence for a role of somatic cellular senescence in physiological aging
but also in injury and disease. Cell cycle inhibitor p16 INK4a is the key mediator for stress …

Telomeres of most somatic cells progressively shorten, compromising the regenerative
capacity of human tissues during aging and chronic diseases and after acute injury. Whether …

Background The G1 cell cycle inhibitors tissue inhibitor of metalloproteinase-2 (TIMP-2) and
insulin-like growth factor-binding protein 7 (IGFBP7) have been identified as promising …

Early identification of patients with acute kidney injury (AKI) being at high risk for adverse
outcome can influence medical treatment. This study compares urinary calprotectin, kidney …

The analysis of kidney malformation caused by environmental influences during nephrogenesis
or by hereditary nephropathies requires animal models allowing the in vivo observation …

Background and aims: Thrombospondin 1 (TSP-1) is an important activator of latent transforming
growth factor β (TGF-β) but little is known of the expression patterns and functions of …

Background We analysed in a carefully phenotyped cohort of paediatric patients the association
of serum angiotensin II type 1 receptor antibodies (AT 1 R-Ab) with specific histological …

Purpose Fetal akinesia has multiple clinical subtypes with over 160 gene associations, but
the genetic etiology is not yet completely understood. Methods In this study, 51 patients from …

Objectives: To determine and quantify risk factors for postoperative pediatric delirium. Design:
Single-center prospective cohort study. Setting: Twenty-two bed PICU in a tertiary care …