Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Background Cerebral microbleeds can confer a high risk of intracerebral hemorrhage, ischemic
stroke, death and dementia, but estimated risks remain imprecise and often conflicting. …

Objective: Our aim was to test the association of vascular risk factor exposure in midlife with
progression of MRI markers of brain aging and measures of cognitive decline. Methods: A …

Background and Purpose— White matter hyperintensities and MRI-defined brain infarcts (BIs)
have individually been related to stroke, dementia, and mortality in population-based …

Background and Purpose— Previous estimates of the prevalence of silent cerebral
infarction (SCI) on MRI in community-based samples have varied between 5.8% and 17.7% …

Objective: Higher dietary intake and circulating levels of docosahexaenoic acid (DHA) and
eicosapentaenoic acid (EPA) have been related to a reduced risk for dementia, but the …

Background Previous studies have identified effects of age and vascular risk factors on
brain injury in elderly individuals. We aimed to establish whether the effects of high blood …

Background— Cardiac dysfunction is associated with neuroanatomic and neuropsychological
changes in aging adults with prevalent cardiovascular disease, theoretically because …

Objective Midlife obesity has been associated with an increased risk of dementia. The
underlying mechanisms are poorly understood. Our aim was to examine the cross‐sectional …

Objective: To determine the association of arterial stiffness and pressure pulsatility, which can
damage small vessels in the brain, with vascular and Alzheimer-type brain aging. Methods…