Chemokines have long been implicated in the initiation and amplification of inflammatory
responses by virtue of their role in leukocyte chemotaxis. The expression of one of the …

Evidence has emerged suggesting a role for the cannabinoid CB 2 receptor in immune cell
motility. This provides a rationale for a novel and generalized immunoregulatory role for …

Inhibition of γ-secretase, one of the enzymes responsible for the cleavage of the amyloid
precursor protein (APP) to produce the pathogenic β-amyloid (Aβ) peptides, is an attractive …

Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset
of patients. Here, we applied single-cell technologies to iCD lesions to address whether …

The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms
related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several …

Background Obesity and inflammation are highly integrated processes in the pathogenesis
of insulin resistance, diabetes, dyslipidemia, and non-alcoholic fatty liver disease. Molecular …

Genetic mutation and pharmacological inhibition of Bruton's tyrosine kinase (Btk) both have
been shown to prevent the development of collagen-induced arthritis (CIA) in mice, …

… The LPS or saline was delivered directly to the trachea with the aid of a fine-tipped
microsprayer (Penn-Century, Philadelphia, PA) and laryngoscope. After recovery from the …

The expression of the cannabinoid peripheral cannabinoid receptor (CB 2 ) receptor on
peripheral immune cells suggests that compounds specific for CB 2 might be effective anti-…

The identification and validation of biomarkers to support the assessment of novel therapeutics
for COPD continues to be an important area of research. The aim of the current study was …