Importance A genetic contribution to preeclampsia susceptibility has been established but is
still incompletely understood. Objective To disentangle the underlying genetic architecture …

Homologous recombination DNA-repair deficiency (HRD) is a common driver of genomic
instability and confers a therapeutic vulnerability in cancer. The accurate detection of somatic …

Understanding the consequences of local adaptation at the genomic diversity is a central
goal in evolutionary genetics of natural populations. In species with large continuous …

Pinus sylvestris (Scots pine) is the most widespread coniferous tree in the boreal forests of
Eurasia, with major economic and ecological importance. However, its large and repetitive …

STUDY QUESTION Can we identify novel variants associated with polycystic ovary syndrome
(PCOS) by leveraging the unique population history of Northern Europe? SUMMARY …

Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the
primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility…

Background Polycystic ovary syndrome (PCOS) is a complex multifactorial disorder with a
substantial genetic component. However, the clinical manifestations of PCOS are …

Background: Preexisting hypertension increases risk for preeclampsia. We examined whether
a generic blood pressure polygenic risk score (BP-PRS), compared with a preeclampsia-…

Preeclampsia is a vascular pregnancy disorder that affects 3-5% of all pregnancies. Genetic
contribution to preeclampsia susceptibility is well established, but the actual risk loci have …

Polycystic ovary syndrome (PCOS) and its underlying features remain poorly understood. In
this genetic and proteomic study, we expand the number of genetic loci from 19 to 29, and …