Pro-oxidant activity of flavonoids induces EpRE-mediated gene expression

…, AH Westphal, WJH van Berkel, JM Aarts… - Chemical research in …, 2006 - ACS Publications
Flavonoids are important bioactive dietary compounds. They induce electrophile-responsive
element (EpRE)-mediated expression of enzymes, such as NAD(P)H−quinone …

Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the …

JT Sanderson, JM Aarts, A Brouwer, KL Froese… - Toxicology and applied …, 1996 - Elsevier
A recombinant H4IIE rat hepatoma cell line (H4L1.1c4, H4IIE-luc), containing a luciferase
reporter gene under control of dioxin-responsive enhancers, was examined for …

Species-specific antagonism of Ah receptor action by 2, 2′, 5, 5′-tetrachloro-and 2, 2′, 3, 3′, 4, 4′-hexachlorobiphenyl

JM Aarts, MS Denison, MA Cox, MAC Schalk… - European Journal of …, 1995 - Elsevier
Using recombinant cell lines showing Ah receptor-controlled expression of a luciferase
reporter gene, the interaction of di-ortho-substituted polychlorinated biphenyls (PCBs) with Ah …

[HTML][HTML] Time-and dose-dependent effects of curcumin on gene expression in human colon cancer cells

…, S Huybers, PJ Van Bladeren, JM Aarts… - Journal of …, 2004 - ncbi.nlm.nih.gov
Background Curcumin is a spice and a coloring food compound with a promising role in colon
cancer prevention. Curcumin protects against development of colon tumors in rats treated …

Validation and use of the CALUX‐bioassay for the determination of dioxins and PCBs in bovine milk

…, WA Traag, T Zuidema, JM Aarts… - Food Additives & …, 1998 - Taylor & Francis
There is a strong need for the development of relatively cheap and rapid bioassays for the
determination of dioxins and related compounds in food. A newly developed CALUX (…

Role of catechin quinones in the induction of EpRE-mediated gene expression

…, L de Haan, JM Aarts… - Chemical research in …, 2008 - ACS Publications
In the present study, the ability of green tea catechins to induce electrophile-responsive
element (EpRE)-mediated gene expression and the role of their quinones in the mechanism of …

Stable reporter cell lines for peroxisome proliferator-activated receptor γ (PPARγ)-mediated modulation of gene expression

…, J Keijer, IMCM Rietjens, B van der Burg, JM Aarts - Analytical …, 2011 - Elsevier
Activation of peroxisome proliferator-activated receptor γ (PPARγ) by ligands is associated
with beneficial health effects, including anti-inflammatory and insulin-sensitizing effects. The …

Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity

…, PJ Van Bladeren, IMCM Rietjens, JM Aarts - Biochemical …, 2006 - Elsevier
The electrophile-responsive element (EpRE) is a transcriptional enhancer involved in
cancer-chemoprotective gene expression modulation by certain food components. Two stably …

[HTML][HTML] Developmental toxicity of thyroid-active compounds in a zebrafish embryotoxicity test

…, AACM Peijnenburg, JM Aarts… - ALTEX-Alternatives to …, 2014 - altex.org
Zebrafish embryos were exposed to concentration ranges of selected thyroid-active model
compounds in order to assess the applicability of zebrafish-based developmental scoring …

GSTP1 and GSTA1 Polymorphisms Interact with Cruciferous Vegetable Intake in Colorectal Adenoma Risk

MJ Tijhuis, PA Wark, JM Aarts, MHPW Visker… - … Biomarkers & Prevention, 2005 - AACR
The possible interplay between cruciferous vegetable consumption, functional genetic variations
in glutathione S-transferases (GST) M1, T1, P1, and A1, and colorectal adenomas, was …