User profiles for Jack A. Tuszynski

Jack Tuszyński

Politecnico di Torino
Verified email at polito.it
Cited by 19329

Quantum computation in brain microtubules: Decoherence and biological feasibility

S Hagan, SR Hameroff, JA Tuszyński - Physical review E, 2002 - APS
The Penrose-Hameroff orchestrated objective reduction (orch. OR) model assigns a cognitive
role to quantum computations in microtubules within the neurons of the brain. Despite an …

The uniqueness of albumin as a carrier in nanodrug delivery

A Spada, J Emami, JA Tuszynski… - Molecular …, 2021 - ACS Publications
Albumin is an appealing carrier in nanomedicine because of its unique features. First, it is
the most abundant protein in plasma, endowing high biocompatibility, biodegradability, …

[HTML][HTML] Cytoskeletal signaling: is memory encoded in microtubule lattices by CaMKII phosphorylation?

TJA Craddock, JA Tuszynski… - PLoS computational …, 2012 - journals.plos.org
Memory is attributed to strengthened synaptic connections among particular brain neurons,
yet synaptic membrane components are transient, whereas memories can endure. This …

[HTML][HTML] A review of the recent development in the synthesis and biological evaluations of pyrazole derivatives

O Ebenezer, M Shapi, JA Tuszynski - Biomedicines, 2022 - mdpi.com
Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an
important class of compounds for drug development; thus, they have attracted much attention. …

[HTML][HTML] The zinc dyshomeostasis hypothesis of Alzheimer's disease

TJA Craddock, JA Tuszynski, D Chopra, N Casey… - PloS one, 2012 - journals.plos.org
Alzheimer's disease (AD) is the most common form of dementia in the elderly. Hallmark AD
neuropathology includes extracellular amyloid plaques composed largely of the amyloid-β …

[HTML][HTML] Structural and evolutionary analysis indicate that the SARS-CoV-2 Mpro is a challenging target for small-molecule inhibitor design

M Bzówka, K Mitusińska, A Raczyńska… - International Journal of …, 2020 - mdpi.com
The novel coronavirus whose outbreak took place in December 2019 continues to spread at
a rapid rate worldwide. In the absence of an effective vaccine, inhibitor repurposing or de …

[HTML][HTML] An overview of molecular modeling for drug discovery with specific illustrative examples of applications

M Aminpour, C Montemagno, JA Tuszynski - Molecules, 2019 - mdpi.com
In this paper we review the current status of high-performance computing applications in the
general area of drug discovery. We provide an introduction to the methodologies applied at …

[PDF][PDF] A biopolymer transistor: electrical amplification by microtubules

A Priel, AJ Ramos, JA Tuszynski, HF Cantiello - Biophysical journal, 2006 - cell.com
Microtubules (MTs) are important cytoskeletal structures engaged in a number of specific
cellular activities, including vesicular traffic, cell cyto-architecture and motility, cell division, and …

Emission of mitochondrial biophotons and their effect on electrical activity of membrane via microtubules

M Rahnama, JA Tuszynski, I Bokkon… - Journal of integrative …, 2011 - World Scientific
In this paper we argue that, in addition to electrical and chemical signals propagating in the
neurons of the brain, signal propagation takes place in the form of biophoton production. …

Automatic prediction of tumour malignancy in breast cancer with fractal dimension

A Chan, JA Tuszynski - Royal Society open science, 2016 - royalsocietypublishing.org
Breast cancer is one of the most prevalent types of cancer today in women. The main
avenue of diagnosis is through manual examination of histopathology tissue slides. Such a …