Mechanistic toxicology provides a powerful approach to inform on the safety of chemicals
and the development of safe‐by‐design compounds. Although toxicogenomics supports …

The intestine is divided into functionally distinct regions along the anteroposterior (A/P) axis.
How the regional identity influences the function of intestinal stem cells (ISCs) and their …

The study of multi-walled carbon nanotube (MWCNT) induced immunotoxicity is crucial for
determining hazards posed to human health. MWCNT exposure most commonly occurs via …

Nutrient-dependent gene regulation critically contributes to homeostatic control of animal
physiology in changing nutrient landscape. In Drosophila, dietary sugars activate transcription …

Mechanistic toxicology has emerged as a powerful framework to inform on the safety of
chemicals and guide the development of new safe-by-design compounds. Although …

Paneth cell niche promotes the function of intestinal stem cells (ISCs) during reduced food
intake, but how ISC activity can be boosted when availability of resources is simultaneously …

Intestine is divided into functionally distinct regions along the anteroposterior (A/P) axis. How
the regional identity influences the function of intestinal stem cells (ISCs) and their offspring …

When the capacity of mitochondrial ribosomes (mitoribosomes) to translate genes encoded
in the mitochondrial genome (mtDNA) is impaired, severe effects on mitochondrial activity …

PGC-1α and its homologues have been proposed to act as master regulators of mitochondrial
biogenesis in animals. Most relevant studies have been conducted in mammals, where …

… Jack Morikka is a postdoctoral researcher at FHAIVE with expertise in molecular biology.
FHAIVE is a research hub in the Faculty of Medicine and Health Technology, Tampere …