Aging with a traumatic brain injury: Could behavioral morbidities and endocrine symptoms be influenced by microglial priming?

…, RK Rowe, MM Muccigrosso, JT Reddaway… - Brain, behavior, and …, 2017 - Elsevier
A myriad of factors influence the developmental and aging process and impact health and
life span. Mounting evidence indicates that brain injury, even moderate injury, can lead to …

[HTML][HTML] Microglial morphometric analysis: so many options, so little consistency

J Reddaway, PE Richardson, RJ Bevan… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Quantification of microglial activation through morphometric analysis has long been a staple
of the neuroimmunologist’s toolkit. Microglial morphological phenomics can be conducted …

Enduring neuroimmunological consequences of developmental experiences: From vulnerability to resilience

J Reddaway, NM Brydges - Molecular and Cellular Neuroscience, 2020 - Elsevier
The immune system is crucial for normal neuronal development and function (neuroimmune
system). Both immune and neuronal systems undergo significant postnatal development …

Neuroimmunological effects of early life experiences

NM Brydges, J Reddaway - Brain and Neuroscience …, 2020 - journals.sagepub.com
Exposure to adverse experiences during development increases the risk of psychiatric
illness later in life. Growing evidence suggests a role for the neuroimmune system in this …

Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder

…, M Toneva, AI Baloc, AL Moon, J Reddaway… - Brain, Behavior, and …, 2022 - Elsevier
Complement is a key component of the immune system with roles in inflammation and host-defence.
Here we reveal novel functions of complement pathways impacting on emotional …

ECCO–A new initiative to support early-career researchers in the complement field

…, AI Lokki, K Mallah, D Nord, J Reddaway… - Molecular …, 2022 - Elsevier
Research on the complement system, like most areas of immunology, has seen tremendous
progress over the last decades. Further advances in the complement field will rely on the …

[HTML][HTML] Early-Career Complementologists (ECCO)–Past achievements and future directions

…, AI Lokki, K Mallah, D Nord, J Reddaway… - Molecular …, 2022 - Elsevier
The Early-Career Complementologists (ECCO) is a task force that was established, in close
collaboration with the European Complement Network (ECN) and the International …

The role of the complement system in associative learning and risk for schizophrenia

J Reddaway - 2022 - orca.cardiff.ac.uk
Schizophrenia and post-traumatic stress disorder are neuropsychiatric disorders which in part
are characterised by impairments in the acquisition and updating of associative memories. …

Manipulating immune pathways differentially impact emotionality: Dissociable effects of complement C3 and C3aR on learned fear and innate anxiety

…, SA Brain, EL Bush, M Toneva, AL Moon, J Reddaway… - bioRxiv, 2019 - biorxiv.org
Background Recent findings implicate complement, a key component of the immune system,
in healthy brain functioning and risk for psychiatric disorders. Altered emotional function, in …

Differential ability of the dorsal and ventral rat hippocampus to exhibit group I metabotropic glutamate receptor–dependent synaptic and intrinsic plasticity

P Tidball, HV Burn, KL Teh… - Brain and …, 2017 - journals.sagepub.com
Background: The hippocampus is critically involved in learning and memory processes.
Although once considered a relatively homogenous structure, it is now clear that the …