The gut microbiome has important effects on human health, yet its importance in human
ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late …

Background: Currently available biomarkers of Alzheimer’s disease (AD) include cerebrospinal
fluid (CSF) protein analysis and amyloid PET imaging, each of which has limitations. The …

Little is known about mechanisms that drive the development of progressive multiple sclerosis
(MS), although inflammatory factors, such as macrophage migration inhibitory factor (MIF), …

Background Women who seek vaginal birth after cesarean delivery may find limited in-hospital
options. Increasing numbers of women in the United States are delivering by vaginal birth …

Background: Testosterone therapy is the predominant treatment for voice masculinization in
transgender patients. Although lowering of voice fundamental frequency (f 0 ) occurs with …

Background Friedman's curve, despite acknowledged limitations, has greatly influenced
labour management. Interventions to hasten birth are now ubiquitous, challenging the …

We previously discovered microRNAs (miRNAs) in cerebrospinal fluid (CSF) that differentiate
Alzheimer’s disease (AD) patients from Controls. Here we examined the performance of 37 …

An update is available for this article. Background: The strength and duration of immunity
from infection with SARS-CoV-2 are important for public health planning and clinical practice. …

Experimental autoimmune encephalomyelitis (EAE) is commonly used as an animal model
for evaluating clinical, histological and immunological processes potentially relevant to the …

Background: Articular cartilage lacks the ability for intrinsic repair after acute injury, and focal
articular cartilage lesions cause significant morbidity worldwide. Arthroscopic debridement (…