User profiles for Jacklyn N Hellwege
Jacklyn N. HellwegeResearch Assistant Professor, Division of Genetic Medicine, Vanderbilt University Medical … Verified email at vanderbilt.edu Cited by 3832 |
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …
We report the largest genetic association study of blood pressure traits (systolic, diastolic …
A catalog of genetic loci associated with kidney function from analyses of a million individuals
…, TB Harris, CA Hartman, C Hayward, JN Hellwege… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood
pressure to identify genes, tissues, phenomes and medication contexts of blood pressure …
pressure to identify genes, tissues, phenomes and medication contexts of blood pressure …
Genome-wide polygenic score to predict chronic kidney disease across ancestries
Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …
Population stratification in genetic association studies
Population stratification (PS) is a primary consideration in studies of genetic determinants of
human traits. Failure to control for PS may lead to confounding, causing a study to fail for …
human traits. Failure to control for PS may lead to confounding, causing a study to fail for …
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
…, KL Duffin, SS Pullen, TL Edwards, JN Hellwege… - Nature …, 2021 - nature.com
The functional interpretation of genome-wide association studies (GWAS) is challenging
due to the cell-type-dependent influences of genetic variants. Here, we generated …
due to the cell-type-dependent influences of genetic variants. Here, we generated …
Obesity and pelvic organ prolapse: a systematic review and meta-analysis of observational studies
Background Studies evaluating the association between obesity and pelvic organ prolapse
report estimates that range from negative to positive associations. Heterogeneous definitions …
report estimates that range from negative to positive associations. Heterogeneous definitions …
[HTML][HTML] A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
…, C Yao, AT Kraja, JH Cartwright, JN Hellwege… - Nature …, 2020 - nature.com
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor
allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we …
allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we …
[HTML][HTML] Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program
Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR),
contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide …
contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide …