Polyethylene glycol (PEG) and other bioactive solutions with neurorrhaphy for rapid and dramatic repair of peripheral nerve lesions by PEG-fusion
…, DM Jackson, T Smith, J Nguyen… - Journal of neuroscience …, 2019 - Elsevier
Background Nervous system injuries in mammals often involve transection or segmental loss
of peripheral nerves. Such injuries result in functional (behavioral) deficits poorly restored …
of peripheral nerves. Such injuries result in functional (behavioral) deficits poorly restored …
[HTML][HTML] Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques
…, K Schultheis, H Pugh, J Nguyen… - Human Vaccines & …, 2019 - Taylor & Francis
ABSTRACT Lassa virus (LASV) is a hemorrhagic fever virus of the Arenaviridae family with
high rates of mortality and co-morbidities, including chronic seizures and permanent bilateral …
high rates of mortality and co-morbidities, including chronic seizures and permanent bilateral …
[HTML][HTML] Immunophenotyping of acute inflammatory exacerbations of lung injury driven by mutant surfactant protein-C: a role for inflammatory eosinophils
J Nguyen, BS Armstrong, S Cowman… - Frontiers in …, 2022 - frontiersin.org
Acute inflammatory exacerbations (AIEs) represent immune-driven deteriorations of many
chronic lung conditions, including COPD, asthma, and pulmonary fibrosis (PF). The first line of …
chronic lung conditions, including COPD, asthma, and pulmonary fibrosis (PF). The first line of …
Parenchymal and Inflammatory Cell Responses to Single and Repeated Ozone Exposure in Healthy and Surfactant Protein-C Mutant Lung
J Nguyen, CE Deering-Rice, BS Armstrong… - Toxicological …, 2022 - academic.oup.com
Mutations in the alveolar epithelial-specific gene encoding for surfactant protein C (SP-C)
are linked to pulmonary disease. Ozone (O 3 ) is a ubiquitous pollutant known to exacerbate …
are linked to pulmonary disease. Ozone (O 3 ) is a ubiquitous pollutant known to exacerbate …
Active immunoprophylaxis and vaccine augmentations mediated by a novel plasmid DNA formulation
NN Schommer, J Nguyen, BS Yung… - Human Gene …, 2019 - liebertpub.com
Plasmid DNA (pDNA) gene delivery is a highly versatile technology that has the potential to
address a multitude of unmet medical needs. Advances in pDNA delivery to host tissue with …
address a multitude of unmet medical needs. Advances in pDNA delivery to host tissue with …
Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and …
K Schultheis, HM Pugh, J Oh, J Nguyen… - Human Vaccines & …, 2020 - Taylor & Francis
Respiratory Syncytial virus (RSV) is a major threat to many vulnerable populations. There
are currently no approved vaccines, and RSV remains a high unmet global medical need. …
are currently no approved vaccines, and RSV remains a high unmet global medical need. …
Protein immunization induces memory CD4+ T cells that lack Th lineage commitment
…, CL Novis, A Baessler, J Nguyen… - The Journal of …, 2021 - journals.aai.org
Acute viral infection generates lineage-committed Th1 and T follicular helper (Tfh) memory
cells that recall their lineage-specific functions following secondary challenge with virus. …
cells that recall their lineage-specific functions following secondary challenge with virus. …
Optimized interferon-gamma ELISpot assay to measure T cell responses in the guinea pig model after vaccination
…, HM Pugh, BS Yung, J Oh, J Nguyen… - JoVE (Journal of …, 2019 - jove.com
The guinea pig has played a pivotal role as a relevant small animal model in the development
of vaccines for infectious diseases such as tuberculosis, influenza, diphtheria, and viral …
of vaccines for infectious diseases such as tuberculosis, influenza, diphtheria, and viral …
Breathing dysfunction and alveolar damage in a mouse model of Dravet syndrome
MJ Goh, CE Deering-Rice, J Nguyen, E Duyvesteyn… - bioRxiv, 2022 - biorxiv.org
Objective The incidence of Sudden Unexpected Death in Epilepsy (SUDEP) is especially high
in those with Dravet syndrome (DS). Risk factors have been identified, but the mechanism(…
in those with Dravet syndrome (DS). Risk factors have been identified, but the mechanism(…
Effects of Bevacizumab on ARPE-19 gene expression
J Nguyen, P Fukuhara, CM Kenney… - … & Visual Science, 2020 - iovs.arvojournals.org
Purpose: In age-related macular degeneration (AMD), retinal pigment epithelial cells (RPE)
are dysfunctional and drusen formation occurs. Hypoxia results in upregulation of VEGFA …
are dysfunctional and drusen formation occurs. Hypoxia results in upregulation of VEGFA …