The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic
alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral …

Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune
mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families …

Lymphoid follicles (LFs) are responsible for generation of adaptive immune responses in
secondary lymphoid organs and form ectopically during chronic inflammation. A human model …

Disclosures: K. Tsai reported personal fees from Regeneron, grants from Array/Pfizer, grants
from Replimune, and grants from Oncosec outside the submitted work. M. Rosenblum …

Unlike many other hematologic malignancies, Richter syndrome (RS), an aggressive B cell
lymphoma originating from indolent chronic lymphocytic leukemia, is responsive to PD-1 …

A microfluidic organ-on-a-chip model of the human lymphoid follicle that recapitulates
vaccination responses in vitro. Blood-derived cells self assemble into germinal centers in a matrix …

When people get infected with the SARS-CoV-virus, which causes COVID-, why do some
people get mildly sick while others get very sick? Although we know that SARS-CoV-enters the …

Single‐walled carbon nanotubes have many potential beneficial uses, with additional
applications constantly being investigated. Their unique properties, however, create a potential …

Although PD-1 pathway inhibitors are revolutionizing cancer treatment, the mechanisms by
which PD-1 regulates antitumor immunity are not fully understood. To determine PD-1 …

The ability to monitor anti-tumor CD8+ T cell responses in the blood has tremendous
therapeutic potential. Here, we used paired single-cell RNA sequencing and T cell receptor (TCR) …