Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …

We read with interest the CREDIBLECR study on cefiderocol treatment of carbapenem-resistant
infections by Matteo Bassetti and colleagues. 1 Cefiderocol had similar efficacy to best …

Cefiderocol is a novel siderophore-cephalosporin conjugate antibiotic approved for treatment
of Gram-negative bacterial infections. In-vitro laboratory testing found cefiderocol to be …

Manganese (Mn) is an essential micronutrient critical for the pathogenesis of Staphylococcus
aureus , a significant cause of human morbidity and mortality. Paradoxically, excess Mn is …

Antibiotics are considered one of the most important contributions to clinical medicine in the
last century. Due to the use and overuse of these drugs, there have been increasing …

Two-component signaling systems (TCSs) are one of the mechanisms that bacteria employ
to sense and adapt to changes in the environment. A prototypical TCS functions as a …

The rising problem of antimicrobial resistance in Staphylococcus aureus necessitates the
discovery of novel therapeutic targets for small-molecule intervention. A major obstacle of drug …

Natural killer (NK) cell leukemia is characterized by clonal expansion of CD3 − NK cells and
comprises both chronic and aggressive forms. Currently no effective treatment exists, thus …

The gut-brain axis, a bidirectional signaling network between the intestine and the central
nervous system, is crucial to the regulation of host physiology and inflammation. Recent …

Staphylococcus aureus is responsible for a significant amount of devastating disease. Its
ability to colonize the host and cause infection is supported by a variety of proteins that are …