The CF 2 H group, a potential surrogate for the OH group, can act as an unusual hydrogen
bond donor, as confirmed by crystallographic, spectroscopic, and computational methods. …

Lumbar disc degeneration is one of the leading causes of chronic low back pain. The
degenerative cascade is often initiated by an imbalance between catabolic and anabolic …

N-terminal acetylation is ubiquitous among eukaryotic proteins and controls a myriad of
biological processes. Of the N-terminal acetyltransferases (NATs) that facilitate this …

Decreasing the size of spectroscopic probes can afford higher-resolution structural information
from fluorescence experiments. Therefore, we have developed p-cyanophenylalanine (…

Purpose The addition of immunotherapy, including a combination of anti-GD2 monoclonal
antibody (mAb), ch14. 18, and cytokines, improves outcome for patients with high-risk …

The appearance of plant organs mediated the explosive radiation of land plants, which
shaped the biosphere and allowed the establishment of terrestrial animal life. The evolution of …

The vast amount of fast excitatory neurotransmission in the mammalian central nervous
system is mediated by AMPA-subtype glutamate receptors (AMPARs). As a result, AMPAR-…

The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein conformational
change because it is a long lifetime, visible wavelength fluorophore that is small enough to …

Thioamide modifications of the peptide backbone are used to perturb secondary structure,
to inhibit proteolysis, as photoswitches, and as spectroscopic labels. Thus far, their …

Previously we have shown that thioamides can be incorporated into proteins as minimally
perturbing fluorescence-quenching probes to study protein dynamics, folding, and aggregation…