User profiles for Jacob Hepkema

Jacob Hepkema

PhD Student, University of Cambridge and Wellcome Sanger Institute
Verified email at cam.ac.uk
Cited by 6

[HTML][HTML] Predicting the impact of sequence motifs on gene regulation using single-cell data

J Hepkema, NK Lee, BJ Stewart, S Ruangroengkulrith… - Genome Biology, 2023 - Springer
The binding of transcription factors at proximal promoters and distal enhancers is central to
gene regulation. Identifying regulatory motifs and quantifying their impact on expression …

Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing

K Tomberg, L Antunes, YY Pan, J Hepkema… - bioRxiv, 2021 - biorxiv.org
The natural habitat of SARS-CoV-2 is the cytoplasm of a mammalian cell where it replicates
its genome and expresses its proteins. While SARS-CoV-2 genes and hence its codons are …

Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing (preprint)

K Tomberg, L Antunes, YY Pan, J Hepkema… - 2021 - pesquisa.bvsalud.org
The natural habitat of SARS-CoV-2 is the cytoplasm of a mammalian cell where it replicates
its genome and expresses its proteins. While SARS-CoV-2 genes and hence its codons are …

[PDF][PDF] Nassau en Friesland

Y Kuiper - Virtus| Journal of Nobility Studies, 2001 - ugp.rug.nl
… Het was de bekende Heerenveense krantenuitgever en publicist Jacob Hepkema geweest
die de jonge Wagenaar indertijd had gestimuleerd in het Fries te schrijven over Friese …

[PDF][PDF] Newspaper dynamics and crime reporting

PJ Shoemaker, SD Reese - scholarlypublications …
This chapter looks at the Dutch newspaper market and the factors that influenced the selection
and presentation of stories of private violence. To do this, it draws on the model presented …

CSIR Synthetic Biology and Precision Medicine Centre Biofoundry Program: Development for first of its kind Biofoundry lab in Africa

DB Thimiri Govindaraj - 2023 - researchspace.csir.co.za
Background: Global bio-foundry Alliance (GBA) has been established between countries
including the UK, US, Japan, Singapore, China, Australia, Denmark, and Canada through 16 …

Predicting efficiency of writing short sequences into the genome using prime editing

J Koeppel, EM Peets, J Weller, A Pallaseni, F Liberante… - bioRxiv, 2021 - biorxiv.org
Short sequences can be precisely written into a selected genomic target using prime editing.
This ability facilitates protein tagging, correction of pathogenic deletions, and many other …

[HTML][HTML] Antigen and cell-based assays for the detection of non-HLA antibodies

RGM Lammerts, D Altulea, BG Hepkema… - Frontiers in …, 2022 - frontiersin.org
To date, human leukocyte antigens (HLA) have been the major focus in the approach to acute
and chronic antibody-mediated rejection (AMBR) in solid-organ transplantation. However, …

[HTML][HTML] Weak expression of terminal complement in active antibody-mediated rejection of the kidney

…, MC van den Heuvel, BG Hepkema… - Frontiers in …, 2022 - frontiersin.org
Background The role of the complement system in antibody-mediated rejection (ABMR) is
insufficiently understood. We aimed to investigate the role of local and systemic complement …

Machine-perfused donor kidneys as a source of human renal endothelial cells

…, MR Daha, MA Seelen, BG Hepkema… - American journal …, 2021 - journals.physiology.org
Renal endothelial cells (ECs) play crucial roles in vasorelaxation, ultrafiltration, and selective
transport of electrolytes and water, but also in leakage of the glomerular filtration barrier …