Plants respond to environmental conditions not only by plastic changes to their own development
and physiology, but also by altering the phenotypes expressed by their offspring. This …

Plants have evolved an array of defenses against pathogens. However, mounting a defense
response frequently comes with the cost of a reduction in growth and reproduction, carrying …

Although there is keen interest in the potential adaptive value of epigenetic variation, it is
unclear what conditions favor the stability of these variants either within or across generations. …

Environmental stresses experienced by individual parents can influence offspring
phenotypes in ways that enhance survival under similar conditions. Although such adaptive …

Stressful parental (usually maternal) environments can dramatically influence expression of
traits in offspring, in some cases resulting in phenotypes that are adaptive to the inducing …

To identify key regulators of human brain tumor maintenance and initiation, we performed
multiple genome-wide RNAi screens in patient-derived glioblastoma multiforme (GBM) stem …

To identify new candidate therapeutic targets for glioblastoma multiforme, we combined
functional genetics and glioblastoma network modeling to identify kinases required for the …

The H1 linker histones are abundant chromatin-associated DNA-binding proteins. Recent
evidence suggests that linker histones also may function through protein–protein interactions. …

During mitosis, the spindle assembly checkpoint (SAC) monitors the attachment of kinetochores
(KTs) to the plus ends of spindle microtubules (MTs) and prevents anaphase onset until …

Incorrect attachment of kinetochore microtubules is the leading cause of chromosome
missegregation in cancers. The highly conserved chromosomal passenger complex (CPC), …