User profiles for Jacob K. Rosenstein
Jacob RosensteinAssociate Professor of Engineering, Brown University Verified email at brown.edu Cited by 2560 |
Integrated nanopore sensing platform with sub-microsecond temporal resolution
Nanopore sensors have attracted considerable interest for high-throughput sensing of
individual nucleic acids and proteins without the need for chemical labels or complex optics. A …
individual nucleic acids and proteins without the need for chemical labels or complex optics. A …
Differentiation of short, single-stranded DNA homopolymers in solid-state nanopores
In the last two decades, new techniques that monitor ionic current modulations as single
molecules pass through a nanoscale pore have enabled numerous single-molecule studies. …
molecules pass through a nanoscale pore have enabled numerous single-molecule studies. …
[PDF][PDF] High-bandwidth protein analysis using solid-state nanopores
High-bandwidth measurements of the ion current through hafnium oxide and silicon nitride
nanopores allow the analysis of sub-30 kD protein molecules with unprecedented time …
nanopores allow the analysis of sub-30 kD protein molecules with unprecedented time …
Slow DNA transport through nanopores in hafnium oxide membranes
We present a study of double- and single-stranded DNA transport through nanopores
fabricated in ultrathin (2–7 nm thick) freestanding hafnium oxide (HfO 2 ) membranes. The high …
fabricated in ultrathin (2–7 nm thick) freestanding hafnium oxide (HfO 2 ) membranes. The high …
[HTML][HTML] Integrated circuit-based electrochemical sensor for spatially resolved detection of redox-active metabolites in biofilms
Despite advances in monitoring spatiotemporal expression patterns of genes and proteins
with fluorescent probes, direct detection of metabolites and small molecules remains …
with fluorescent probes, direct detection of metabolites and small molecules remains …
Measurement of DNA translocation dynamics in a solid-state nanopore at 100 ns temporal resolution
Despite the potential for nanopores to be a platform for high-bandwidth study of single-molecule
systems, ionic current measurements through nanopores have been limited in their …
systems, ionic current measurements through nanopores have been limited in their …
In Situ Nanopore Fabrication and Single-Molecule Sensing with Microscale Liquid Contacts
CE Arcadia, CC Reyes, JK Rosenstein - Acs Nano, 2017 - ACS Publications
In this article, we introduce a flexible technique for high-throughput solid-state nanopore
analysis of single biomolecules. By confining the electrolyte to a micron-scale liquid meniscus at …
analysis of single biomolecules. By confining the electrolyte to a micron-scale liquid meniscus at …
A 14.4 nW 122KHz dual-phase current-mode relaxation oscillator for near-zero-power sensors
S Dai, JK Rosenstein - 2015 IEEE custom integrated circuits …, 2015 - ieeexplore.ieee.org
This paper presents a novel ultra-low-power dual-phase current-mode relaxation oscillator,
which produces a 122 kHz digital clock and has total power consumption of 14.4 nW at 0.6 V. …
which produces a 122 kHz digital clock and has total power consumption of 14.4 nW at 0.6 V. …
[HTML][HTML] Multicomponent molecular memory
Multicomponent reactions enable the synthesis of large molecular libraries from relatively
few inputs. This scalability has led to the broad adoption of these reactions by the …
few inputs. This scalability has led to the broad adoption of these reactions by the …
Single ion channel recordings with CMOS-anchored lipid membranes
JK Rosenstein, S Ramakrishnan, J Roseman… - Nano …, 2013 - ACS Publications
We present single-ion-channel recordings performed with biomimetic lipid membranes
which are directly attached to the surface of a complementary metal–oxide–semiconductor (…
which are directly attached to the surface of a complementary metal–oxide–semiconductor (…