The mammalian brain contains few niches for neural stem cells (NSCs) capable of generating
new neurons, whereas other regions are primarily gliogenic. Here we leverage the spatial …

A long-standing goal of spinal cord injury research is to develop effective spinal cord repair
strategies for the clinic. Rat models of spinal cord injury provide an important mammalian …

Primary astrocyte cell cultures have become a valuable tool for studies of signaling pathways
that regulate astrocyte physiology, reactivity, and function; however, differences in culture …

Scar formation after brain injury is still poorly understood. To further elucidate such processes,
here, we examine the interplay between astrocyte proliferation taking place predominantly …

We investigated whether imatinib (Gleevec®, Novartis), a tyrosine kinase inhibitor, could
improve functional outcome in experimental spinal cord injury. Rats subjected to contusion …

After contusion spinal cord injury (SCI), astrocytes become reactive and form a glial scar.
While this reduces spreading of the damage by containing the area of injury, it inhibits …

The complexity of signaling events and cellular responses unfolding in neuronal, glial, and
immune cells upon traumatic brain injury (TBI) constitutes an obstacle in elucidating …

A number of different rodent experimental models of spinal cord injury have been used in
an attempt to model the pathophysiology of human spinal cord injury. As a result, …

Central nervous system (CNS) injury results in chronic scar formation that interferes with
function and inhibits repair. Extracellular matrix (ECM) is prominent in the scar and potently …

With no currently available drug treatment for spinal cord injury, there is a need for additional
therapeutic candidates. We took the approach of repositioning existing pharmacological …