User profiles for Jacob N. Sanders
Jacob SandersNIH Postdoctoral Scholar, University of California, Los Angeles Verified email at chem.ucla.edu Cited by 861 |
[HTML][HTML] 14 examples of how LLMs can transform materials science and chemistry: a reflection on a large language model hackathon
… Extracting structured data from free-form organic synthesis text Qianxiang Ai, Jacob N.
Sanders, Jiale Shi, Stefan Bringuier, Brenden Pelkie, Marcus Schwarting image file: d3dd00113j-…
Sanders, Jiale Shi, Stefan Bringuier, Brenden Pelkie, Marcus Schwarting image file: d3dd00113j-…
Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C–H bonds
C–H functionalization represents a promising approach for the synthesis of complex molecules.
Instead of relying on modifying the functional groups present in a molecule, the synthetic …
Instead of relying on modifying the functional groups present in a molecule, the synthetic …
Enantioselective C–H functionalization of bicyclo [1.1. 1] pentanes
ZJ Garlets, JN Sanders, H Malik, C Gampe, KN Houk… - Nature Catalysis, 2020 - nature.com
Bicyclo[1.1.1]pentanes (BCPs) are highly strained carbocycles that have fascinated the chemical
community for decades because of their unique structure. Despite the immense interest …
community for decades because of their unique structure. Despite the immense interest …
Structure and function of NzeB, a versatile C–C and C–N bond-forming diketopiperazine dimerase
The dimeric diketopiperazine (DKPs) alkaloids are a diverse family of natural products (NPs)
whose unique structural architectures and biological activities have inspired the …
whose unique structural architectures and biological activities have inspired the …
Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase
…, Y Ye, VV Shende, F Yu, JN Sanders… - Nature …, 2019 - nature.com
Prenylated indole alkaloids such as the calmodulin-inhibitory malbrancheamides and
anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here, …
anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here, …
Compressed sensing for multidimensional spectroscopy experiments
Compressed sensing is a processing method that significantly reduces the number of
measurements needed to accurately resolve signals in many fields of science and engineering. …
measurements needed to accurately resolve signals in many fields of science and engineering. …
Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases
A Matthews, R Saleem-Batcha, JN Sanders… - Nature chemical …, 2020 - nature.com
One of the hallmark reactions catalyzed by flavin-dependent enzymes is the incorporation of
an oxygen atom derived from dioxygen into organic substrates. For many decades, these …
an oxygen atom derived from dioxygen into organic substrates. For many decades, these …
Molecular dynamics simulations guide chimeragenesis and engineered control of chemoselectivity in diketopiperazine dimerases
VV Shende, NR Harris, JN Sanders… - Angewandte Chemie …, 2023 - Wiley Online Library
In the biosynthesis of the tryptophan‐linked dimeric diketopiperazines (DKPs), cytochromes
P450 selectively couple DKP monomers to generate a variety of intricate and isomeric …
P450 selectively couple DKP monomers to generate a variety of intricate and isomeric …
[HTML][HTML] Initiation of fatty acid biosynthesis in Pseudomonas putida KT2440
Deciphering the mechanisms of bacterial fatty acid biosynthesis is crucial for both the engineering
of bacterial hosts to produce fatty acid-derived molecules and the development of new …
of bacterial hosts to produce fatty acid-derived molecules and the development of new …
Enzymatic control of dioxygen binding and functionalization of the flavin cofactor
R Saleem-Batcha, F Stull, JN Sanders… - Proceedings of the …, 2018 - National Acad Sciences
The reactions of enzymes and cofactors with gaseous molecules such as dioxygen (O 2 ) are
challenging to study and remain among the most contentious subjects in biochemistry. To …
challenging to study and remain among the most contentious subjects in biochemistry. To …