User profiles for Jacob N. Sanders

Jacob Sanders

NIH Postdoctoral Scholar, University of California, Los Angeles
Verified email at chem.ucla.edu
Cited by 861

[HTML][HTML] 14 examples of how LLMs can transform materials science and chemistry: a reflection on a large language model hackathon

…, B Ranković, SG Rodriques, JN Sanders… - Digital …, 2023 - pubs.rsc.org
… Extracting structured data from free-form organic synthesis text Qianxiang Ai, Jacob N.
Sanders, Jiale Shi, Stefan Bringuier, Brenden Pelkie, Marcus Schwarting image file: d3dd00113j-…

Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C–H bonds

K Liao, YF Yang, Y Li, JN Sanders, KN Houk… - Nature …, 2018 - nature.com
C–H functionalization represents a promising approach for the synthesis of complex molecules.
Instead of relying on modifying the functional groups present in a molecule, the synthetic …

Enantioselective C–H functionalization of bicyclo [1.1. 1] pentanes

ZJ Garlets, JN Sanders, H Malik, C Gampe, KN Houk… - Nature Catalysis, 2020 - nature.com
Bicyclo[1.1.1]pentanes (BCPs) are highly strained carbocycles that have fascinated the chemical
community for decades because of their unique structure. Despite the immense interest …

Structure and function of NzeB, a versatile C–C and C–N bond-forming diketopiperazine dimerase

…, Y Khatri, SA Newmister, JN Sanders… - Journal of the …, 2020 - ACS Publications
The dimeric diketopiperazine (DKPs) alkaloids are a diverse family of natural products (NPs)
whose unique structural architectures and biological activities have inspired the …

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase

…, Y Ye, VV Shende, F Yu, JN Sanders… - Nature …, 2019 - nature.com
Prenylated indole alkaloids such as the calmodulin-inhibitory malbrancheamides and
anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here, …

Compressed sensing for multidimensional spectroscopy experiments

JN Sanders, SK Saikin, S Mostame… - The journal of …, 2012 - ACS Publications
Compressed sensing is a processing method that significantly reduces the number of
measurements needed to accurately resolve signals in many fields of science and engineering. …

Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases

A Matthews, R Saleem-Batcha, JN Sanders… - Nature chemical …, 2020 - nature.com
One of the hallmark reactions catalyzed by flavin-dependent enzymes is the incorporation of
an oxygen atom derived from dioxygen into organic substrates. For many decades, these …

Molecular dynamics simulations guide chimeragenesis and engineered control of chemoselectivity in diketopiperazine dimerases

VV Shende, NR Harris, JN Sanders… - Angewandte Chemie …, 2023 - Wiley Online Library
In the biosynthesis of the tryptophan‐linked dimeric diketopiperazines (DKPs), cytochromes
P450 selectively couple DKP monomers to generate a variety of intricate and isomeric …

[HTML][HTML] Initiation of fatty acid biosynthesis in Pseudomonas putida KT2440

…, WE Michener, CD Nicora, JN Sanders… - Metabolic …, 2023 - Elsevier
Deciphering the mechanisms of bacterial fatty acid biosynthesis is crucial for both the engineering
of bacterial hosts to produce fatty acid-derived molecules and the development of new …

Enzymatic control of dioxygen binding and functionalization of the flavin cofactor

R Saleem-Batcha, F Stull, JN Sanders… - Proceedings of the …, 2018 - National Acad Sciences
The reactions of enzymes and cofactors with gaseous molecules such as dioxygen (O 2 ) are
challenging to study and remain among the most contentious subjects in biochemistry. To …